New Developments in Oncology Research

Marcos T. Blair (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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In the opening chapter, authors discuss the current literature that describes the application of Palliative Medicine services in advanced cancer, models of Palliative Care delivery by site and mode of practice, cost-effectiveness of early Palliative Medicine referral patterns and national and international Palliative Medicine practice and referral guidelines. The chapter will also discuss the outcomes of Palliative Medicine in Oncology focusing on the improvements in patient clinical and quality of life outcomes.

Next, a systematic chapter aims to better explain the mechanisms that underlie electrolyte disturbances in cancer patients, to stress on the serious prognostic implications involved and to provide practical and useful indications for the prompt diagnosis, management and therapy of electrolyte disorders.

The authors discuss over thirty Pt{η2-P(X)nP}Cl2 (n = 5,6,7,8) derivatives in which organodiphosphines create wide varieties of the metallocyclic rings: eight-membered (PC5P, PC2OC2P, PC2NC2P), nine-membered (PC6P, POC4OP), ten-membered (POC5OP, PC2OCOC2P, PC3OC3P), and eleven-membered (PC8P, PNC6NP, POC6OP). Another included study covers eighty five Pt(II) complexes with an inner coordination sphere of cis- PtP2Cl2. The P- donor ligands are organodiphosphines which create four- and five-membered metallocyclic rings with the PCP, PNP, PC-CP, PC=CP, PN2P and PCOP types. In the penultimate chapter, the authors examine over forty cis-Pt(η2-PXXXP)Cl2 derivatives in which organodiphosphines create six-membered metallocyclic rings, and the concluding chapter examines over thirty cis-Pt(η2-PXXXXP)Cl2 derivatives in which organodihosphines create seven-membered metallocyclic rings.

Preface

Chapter 1. Palliative Care in Oncology
(Laura Finn, MD, and Sonia Malhotra, MD, Division of Hematology and Bone Marrow Transplant, Department of Internal Medicine, Ochsner Medical Center, New Orleans, Louisiana, USA, and others)

Chapter 2. Electrolyte Disorders in Cancer Patients: Clinical Implication and Management
(Rossana Berardi, Francesca Morgese, Silvia Rinaldi, and Mariangela Torniai, Clinica Oncologica, Università Politecnica delle Marche, Azienda Ospedaliero, Universitaria Ospedali Riuniti Umberto I, GM Lancisi, G Salesi, Ancona, Italy)

Chapter 3. Organodiphosphines in Pt{η2-P(X)nP}Cl2 (n = 5,6,7,8) Derivatives: Structural Aspects
(Milan Melník, Mária Bodnár Mikulová, and Peter Mikuš, Comenius University in Bratislava, Faculty of Pharmacy, Department of Pharmaceutical Analysis and Nuclear Pharmacy, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic, and others)

Chapter 4. Organodiphosphines in Cis-Pt(η2-Pxp)(Cl)2 and Cis-Pt(η2-Pxxp)(Cl)2 Derivatives: Structural Aspects
(Milan Melník, Andrea Forgácsová, and Peter Mikuš, Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic, and others)

Chapter 5. Organodiphosphines in Cis – Pt(η2-Pxxxp)cl2 Derivatives: Structural Aspects
(Milan Melník Andrea Forgacsova, and Peter Mikuš, Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic, and others)

Chapter 6. Organodiphosphines in Cis- Pt(η2-Pxxxxp)cl2 Derivatives: Structural Aspects
(Milan Melník Andrea Forgacsova, and Peter Mikuš, Department of Pharmaceutical Analysis and Nuclear Pharmacy, Faculty of Pharmacy, Comenius University in Bratislava, Odbojárov 10, SK-832 32 Bratislava, Slovak Republic, and others)
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