New Developments in Calcium Signaling Research

Masayoshi Yamaguchi, PhD (Editor)
Department of Hematology and Medical Oncology, Emory University, School of Medicine, Atlanta, Georgia, USA

Series: New Developments in Medical Research
BISAC: MED106000



Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick


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The calcium metabolism in the living body is skillfully regulated through calcium-regulating hormones, including the parathyroid hormone, active vitamin D3 metabolite and calcitonin. The blood calcium concentration is ten thousand-fold compared with the levels in cells. Cells use extracellular calcium to regulate cell function efficiently. Intracellular calcium homeostasis is exactly regulated through the mechanism related to various calcium transport systems in cells. Signal transduction plays a pivotal role in cellular regulation.

Calcium signaling is probably the most ubiquitous cellular signal that mediates the action of many hormones, cytokines, and neurotransmitters. Calcium regulates the activity of numerous calcium-dependent proteins including protein kinases, protein phosphatases, protease and other calcium-regulating factors involved in calcium signaling. Calcium signaling plays a pivotal role in the regulation of manifold cellular functions including cell proliferation, apoptosis and gene expression. This book focuses on recent topics in calcium signaling and its related diseases. (Imprint: Nova Biomedical )


Chapter 1. The 1, 25 Dihydroxyvitamin D3-Membrane–Associated, Rapid Response Steroid-Binding Receptor: Physiological Roles and Characterization of Binding Partners
(T.M. Sterling, R.C. Khanal and I. Nemere, Department of Nutrition, Dietetics and Food Science, Utah State University, Logan, Utah, USA, and others)

Chapter 2. Modulation of Airway Epithelial Cell Calcium and Airway Hydration in Cystic Fibrosis: Role of Glucocorticoids and Lipoxins
(Fiona C. Ringholz, Gerard Higgins, Julien M. Buyck and Valérie Urbach, National Children’s Research Centre, Crumlin, Dublin, Ireland, and others)

Chapter 3. Excitation–Transcription Coupling: A Quantitative Approach
(Evgeny Kobrinsky and Nikolai M. Soldatov, National Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA, and others)

Chapter 4. A Novel Concept on the Repetitive Calcium Elevation
(Ruei-Cheng Yang, Wen-Li Hsu, Tohru Yoshioka, Kaohsiung Medical University, Taiwan)

Chapter 5. Calcium-Binding Proteins in the Liver Fluke, Fasciola hepatica
(Sean L. Russell and David J. Timson, School of Biological Sciences, Queen's University Belfast, Medical Biology Centre, Belfast, UK)

Chapter 6. Role of Regucalcin in Calcium Signaling of Kidney Cells
(Masayoshi Yamaguchi, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA)

Chapter 7. Suppressive Role of Regucalcin in Cell Protein Synthesis: Involvement in Calcium Signaling
(Masayoshi Yamaguchi, Department of Hematology and Medical Oncology, Emory University School of Medicine, Atlanta, Georgia, USA)


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