Neuropeptide Y: Molecular Structure, Role in Food Intake and Direct/Indirect Effects

Steven L. Parker, PhD (Editor)
Department of Pharmacology, University of Tennessee Health Sciences Center, Memphis, TN, USA

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions, Neuroscience Research Progress
BISAC: SCI007000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book presents a broad summary of current knowledge concerning the structure and biochemistry of neuropeptide Y in relation to its role in feeding and interactions with receptors, transducers, effectors and channels that can also connect to food intake. The very high conservation of NPY sequence indicates its critical importance in basal metabolic regulation. Mutations connecting to NPY are virtually absent, and those affecting the Y1 and Y2 receptors are very few. From the evidence presented across vertebrate classes, NPY appears mainly as metabotropic driver via the Y1 group of receptors, and its negative metabotropicity through the Y2 receptor is only of importance in the mammal, and then tempered by Y2 receptor masking in the hypothalamus and low numbers in the cortex, and by low availability of NPY outside the forebrain. Anatomically, NPY is well-represented especially in limbic areas of the forebrain, but the feeding-critical presence of Y1 receptors is, at least in the rodent, highest in the neocortex, and evidence presented in this book points to much larger involvement of cortical NPY receptors in feeding regulation than is usually perceived. The strong presence of this highly conserved peptide in the vertebrate forebrain is increasingly documented as linked not only to the regulation of glucose metabolism (and insulin activity), but also as directly involved in the operation of transducers, effectors and channels. This should be enabled especially by the high interactivity of the acidic sector of NPY (which is not shared by NPY-related systemic peptides, peptide YY and pancreatic polypeptide), and results in partial agonism and possibly also in accumulation in the bilayer. NPY could be involved as a helper agonist in several parts of the vertebrate metabolome. (Imprint: Nova Biomedical )

Chapter 1. Chicken Neuropeptide Y in the Control of Appetite and Metabolism
(Takashi Bungo, Jun-ichi Shiraishi, Shin-ichi Kawakami, D. Michael Denbow and Mitsuhiro Furuse, Laboratory of Animal Behavior and Physiology, Graduate School of Biosphere Science, Hiroshima University, Higashi-Hiroshima, Japan, and others)

Chapter 2. Neuropeptide Y (NPY) Relations to Obesity and Metabolic Syndrome
(Flávia Campos Corgosinho and Ana Raimunda Dâmaso, Biosciences Department, Federal University of Sao Paulo-Paulista Medicine School-UNIFESP-EPM, Sao Paulo, Brazil)

Chapter 3. Neuropeptide Y and its Receptors: Molecular Structure and Pathophysiological Role in Food Intake and Energy Homeostasis
(Hidesuke Kaji, Division of Physiology and Metabolism, University of Hyogo, Japan)

Chapter 4. Developmental Role of Neuropeptide Y in the Autonomic Ganglia
(P.M. Masliukov and A.D. Nozdrachev, Department of Normal Physiology, Yaroslavl State Medical Academy, Yaroslavl, Russia, and others)

Chapter 5. Neuropeptide Y in Feeding: Specific and Protean Actions
(Michael S. Parker, Renu Sah, Ambikaipakan Balasubramaniam, Floyd R. Sallee, William R. Crowley and Steven L. Parker, Department of Microbiology and Molecular Cell Sciences, University of Memphis, Memphis TN, USA, and others)

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