Neuroinflammation: Pathogenesis, Mechanisms and Management


Carmelina Gemma (Editor)
University of South Florida College of Medicine, Center of Excellence for Aging and Brain Repair, Department of Neurosurgery, Tampa, FL

Series: Neuroscience Research Progress, Neuroanatomy Research at the Leading Edge
BISAC: MED057000

Today, the neurotoxic and neuroprotective roles of the innate immune reactions in aging, brain injury, autoimmune and neurodegenerative disorders of the CNS are widely investigated and highly debated research topics. Nevertheless, several issues remain to be elucidated, notably the earlier cellular events that initiate dysregulation of brain inflammatory pathways. This book has been prepared to provide an overview of the field of neuroimmunology research. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents



Chapter 1. Inflammation in the Aged Brain
(Carmelina Gemma, Josh Morganti, Justin Rogers, Beth Grimmig, Charles Hudson, Adam D. Bachstetter and Paula C. Bickford)

Chapter 2. Neuroinflammatory Processes in the Pathogenesis of Alzheimer’s Disease
(Mastura Monif and David A. Williams)

Chapter 3. Molecular Mechanisms of Neuroinflammation in Alzheimer’s Disease
(Vanja Vukic, Debbie Callaghan, Hong Liu, Wandong Zhang)

Chapter 4. Neuroinflammation in Parkinson’s Disease: a Role for Matrix Metalloproteinases?
(Maria Egle De Stefano, Valentina Annese, Carlos Barcia, Francisco Ros-Bernal, Emiliano Fernández-Villalba, Maria Trinidad Herrero)

Chapter 5. Neuroinflammatory Factors as Targets Against Neurological and Psychiatric Disorders
(V. Echeverria and R. Zeitlin)
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Chapter 6. Neuroinflammation and Depression
(Izabela Guimaraes Barbosa, Joanna Rybka , Niclas Svedberg, Livia A. Carvalho)

Chapter 7. A Role for Serotonin in the Modulation of Cytokines in the CNS: Insights From a Mouse Model
(Christine F. Hohmann, Carlos A. Pardo, Michelle Ayorinde, Charlene Monu-Azinge, Maria Braileanu, Karen S. Smith-Connor, Mary E. Blue)

Chapter 8. Neuroinflammation in the Pathogenesis of Autism Spectrum Disorders: Converging Evidence for Systemic and Central Nervous System Immune Interaction
(Meghan C. Mott, Rafael Fernandez-Botran, Manuel F. Casanova)

Chapter 9. Comorbid Nervous System Manifestations and Disorders with Myasthenia Gravis: Evidences and Possible Mechanisms
(Sherifa Ahmad Hamed)

Chapter 10. Modulation of Neuroinflammation by Dietary Flavonoids
(David Vauzour, Alison Spilsbury, Katerina Vafeiadou, Marcus Rattray, Jeremy P E Spencer)

Chapter 11. The Potential Role of Common Olfactory Challenges in the Initiation of Neuroinflammation
(Jeannine A. Majde)

Chapter 12. Pattern Recognition Receptor Activation in the Brain and the Influence on Viral Neurovirulence and Neurodegeneration
(Piyali Mukherjee, Niranjan B. Butchi, Karin E. Peterson)

Chapter 13. Idiopathic Intracranial Hypertension May be Caused by Reactivation of Latent Cerebral Toxoplasmosis Due to Various Medications and Biologic Substances
(Joseph Prandota)

Chapter 14. Idiopathic Intracranial Hypertension May be Caused by Reactivation of Latent Cerebral Toxoplasmosis . Effect of Various Diseases and Clinical States
(Joseph Prandota)

Chapter 15. Transient Beneficial Effects of Fever on Behavior of Children with Autistic Spectrum Disorders May be Caused by T. gondii Stage Differentiation During Latent Cerebral Toxoplasmosis, Associated with the Changes in Immune Responses of the Host
(Joseph Prandota)

Chapter 16. Rhesus-Associated Glycoprotein (RhAG) Phenotype of the Red Blood Cells Modulates T. gondii Infection-Associated Psychomotor Performance Reaction Times and Changes in the Human Personality Profile. Impaired Function of the CO2, AQP1, and AQP4 Gas Channels May Cause Hypoxia and Thus Enhance Neuroinflammation in Autistic Individuals
(Joseph Prandota)

Chapter 17. Increased Generation of Antibodies and Autoantibodies Directed Against Brain Proteins in Patients with Autism and Their Families May be Caused by T. gondii Infection. Maternal and Fetal Microchimerisms Probably Play an Important Role in These Processes Acting as a “Trojan Horse” in Dissemination of the Parasite
(Joseph Prandota)


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