Neurofibromatosis: Diagnosis, Management and Clinical Outcomes


Walter Romaine (Editor)

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

Neurofibromatosis Type 1 (NF1) is a hereditary neurocutaneous tumor disorder that owes many of its most common features to abnormalities in neural crest-derived cells. NF1 may cause dysplasia in various tissues, even in some tissues that are non-neural crest-derived (e.g. bone). While common manifestations of NF1 include café-au-lait spots and neurofibromas, vasculopathies are less common yet noteworthy complications of NF1. NF1 vasculopathies can involve vessels supplying various organs. Cerebrovascular abnormalities associated with NF1 have been sporadically described in the literature; these conditions are of interest due to the incomplete understanding of their pathogenesis and genetics. This book discusses the diagnosis, managements and clinical outcomes for neurofibromatosis.

(Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1 – Cervical Pseudoaneurysm Associated with Neurofibromatosis Type 1 (pp. 1-14)
Osamu Hamasaki and Kaoru Kurisu

Chapter 2 – Hematopoietic Lineages Cooperate with Osteoblasts in the Initiation and Progression of Neurofibromatosis Type 1 Associated Skeletal Deficits (pp. 15-44)
Steven D. Rhodes and Feng-Chun Yang

Chapter 3 – Cerebrovascular Complications of Neurofibromatosis Type I (pp. 45-64)
Patrick M. Flanigan and Richard A. Prayson

Chapter 4 – Targeting the Tumor Microenvironment for the Treatment of Plexiform Neurofibromas in Patients with Neurofibromatosis Type 1 (pp. 65-78)
Mia Yang Chen, Steven David Rhodes and David Wade Clapp


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