Neurodegenerative Diseases: From Molecular Concepts to Therapeutic Targets


Rommy von Bernhardi and Nibaldo C. Inestrosa (Editors)
Pontifica Universidad Catolica de Chile, Chile

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED057000

This book discusses in detail the different hypothesis and experimental evidence regarding the neurobiological mechanisms involved in neurodegenerative pathology, with an emphasis in Alzheimer’s and Parkinson’s disease. Since there are many hypotheses for neurodegenerative diseases, there is a real need for a comprehensive view, allowing for integration of the different views for the pathogenic mechanisms of the disease. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter I – Impact of Intracellular Aβ amyloid Peptide in Health and Disease; pp. 1-8
(Claudio Cuello, McGill University, Canada)

Chapter II – Soluble Aβ Oligomers in Alzheimer’s Disease; pp. 9-24
(N. Marcelo, Fernanda G. De Felice, William L. Klein, Universidade Federal do Rio de Janeiro, Brazil)

Chapter III – Inhibitory Effects of Aβ-amyloid Aggregates on Synaptic Transmission in Hippocampal Neurons; pp. 25-37
(L.G.Aguayo, J. Parodi, F.J. Sepúlveda, Universidad de Concepción)

Chapter IV – Role of LIMK1 in Neuronal Degeneration in Alzheimer’s Disease; pp. 39-49
(Alfredo Lorenzo, Lorena Heredia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina)

Chapter V – Amyloid-B-Peptide Activates the Neuronal C-ABL Tyrosine Kinsae/ P73 Signaling Transduction Pathway; pp. 51-61
(Gonzalo I. Cancino, Alejandra R. Alvarez, Facultad de Ciencias Biológicas, Pontificia Universidad Católica de Chile)

Chapter VI – Neuroprotection by Astrocytes Involves Multiple Regulatory Mechanisms; pp. 63-82
(R. von Bernhardi, G. Ramírez, Pontificia Universidad Católica de Chile)

Chapter VII – Wnt Signaling and its Importance in Alzheimer’s Disease; pp. 83-91
(N.C. Inestrosa, M. Colombresi, Pontificia Universidad Católica de Chile)

Chapter VIII – Glycogen Synthase Kinase 3 (GSK-3) As A Molecular Target for Alzheimer’s Disease and Other Tauopathies; pp. 93-110
(Miguel Medina, Neuropharma S.A., Tres Cantos, Spain)

Chapter IX – Inverse Association Between Cancer and Dementia of the Alzheimer’s Type; pp. 111-120
(María I. Behrens, Hospital Clínico Universidad de Chile, Catherine M. Roe, John C Morris, Washington University, USA)

Chapter X – Wnt Signalling in Spinal cord Connectivity: Towards Regeneration of the Central Nervous System?; pp. 121-131
(Juan Pablo Henriquez, Universidad de Concepción, Chile)

Chapter XI – Protein Nitrotyrosination in Alzheimer’s Disease;
pp. 133-143
(Francesc X. Guix, Mireia Coma, Gerard Ill-Raga, Universitat Pompeu Fabra, Barcelona)

Chapter XII – The Ryanodine Receptors / Calcium Release Channels as Neuronal Redox Sensors; pp. 145-158
(Cecilia Hidalgo, Facultad de Medicina, Universidad de Chile, S. Pablo Muñoz, Marco T. Núñez, Facultad de Ciencias, Universidad de Chile)

Chapter XIII – Reactive Oxygen Species Signaling in the Hippocampus; pp. 159-168
(Faridis Serrano, Baylor College of Medicine, USA, Eric Klann, Center for Neural Science, New York University, USA)

Chapter XIV – Role of Copper in Alzheimer‘s Disease and other Neuropathological Disorders; pp. 169-176
(Gerd Multhaup, Freie Universität Berlin, Germany, Thomas A. Bayer, Department of Psychiatry, Saarland University, Germany)

Chapter XV – Zn2+-protein Interactions in Normal Brain Physiology and Neuropathology; pp. 177-187
(C. Opazo, Universidad de Concepción and Program of Basic and Translational Neuroscience, P. Castro, J. Waldron, Universidad de Concepción)

Chapter XVI – Iron Toxicity: A Critical Review on its Role in Parkinson’s Disease; pp. 189-204
(Daniel Bórquez, Pamela Valdés, Marco T. Núñez, Faculty of Sciences, Universidad de Chile, Chile)


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