Neurobiological Correlates of Behavioral and Cognitive Performance in Nonhuman Primates

Gwendolen E. Haley and Jacob Raber
Oregon Health and Science University Portland, OR, and others

Series: Animal Science, Issues and Research
BISAC: SCI070000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Animals in experiments are traditionally grouped by experimental treatment. Although this is a valuable way to differentiate the groups, alternatively, groups can be distinguished based on cognitive performance. Performance based analysis can yield valuable insights, corresponding to behavior and/or cognition, that might not otherwise be observed. This book discusses a cohort of elderly female rhesus macaques who participated in a spatial food port maze navigational test. Circadian activity and pharmacological MRI (phMRI) were assessed in these monkeys in vivo and radioligand binding was assessed in post-mortem tissue. Based on cognitive performance in the spatial maze, the cohort of monkeys was divided into Good Spatial Performers (GSP) and Poor Spatial Performers (PSP). (Imprint: Nova)

ABSTRACT

INTRODUCTION

STUDIES DISCUSSED IN THIS CHAPTER

NONHUMAN PRIMATE SPATIAL MAZE

CIRCADIAN ACTIVITY

BEHAVIORAL OR COGNITIVE CLASSIFICATION

PHMRI

RECEPTOR BINDING ASSAYS

CONCLUSION

ACKNOWLEDGEMENTS

REFERENCES

INDEX

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