Details

Animals in experiments are traditionally grouped by experimental treatment. Although this is a valuable way to differentiate the groups, alternatively, groups can be distinguished based on cognitive performance. Performance based analysis can yield valuable insights, corresponding to behavior and/or cognition, that might not otherwise be observed. This book discusses a cohort of elderly female rhesus macaques who participated in a spatial food port maze navigational test. Circadian activity and pharmacological MRI (phMRI) were assessed in these monkeys in vivo and radioligand binding was assessed in post-mortem tissue. Based on cognitive performance in the spatial maze, the cohort of monkeys was divided into Good Spatial Performers (GSP) and Poor Spatial Performers (PSP). (Imprint: Nova)