Nerve Sheath Tumors: Signs, Symptoms and Treatment

Richard A. Prayson, MD, MEd (Editor)
Cleveland Clinic, Cleveland, OH, US

Series: Neuroscience Research Progress, Rare Disorders Research Progress
BISAC: MED062000, MED056000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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There are a variety of tumors that can arise from various compartments and cellular components of peripheral nerves throughout the body. These peripheral nerve sheath tumors run the gamut from benign, fairly commonly encountered neoplasms such as schwannomas and neurofibromas to rarer, low grade neoplasms and variants such as perineuriomas, mucosal neuromas, palisaded encapsulated neuromas, granular cell tumors and nerve sheath myxomas to malignant neoplasms, so-called malignant peripheral nerve sheath tumors. They are generally classified as soft tissue neoplasms but they differ from most other tumors in this general grouping in a number of ways.

Many of them are associated with genetic disorders or hereditary tumor syndromes and the majority of malignant peripheral nerve sheath tumors arise from a benign precursor tumor, neurofibroma. Their precise diagnosis and classification necessitates careful correlation with clinical and surgical data along with attention to histologic and immunohistochemical features. This text is comprised of a collection of chapters reviewing some of the myriad aspects of this group of neoplasms and includes discussions of the epithelioid variant of malignant peripheral nerve sheaths, peineuriomas arising in the colon, peripheral nerve sheath tumors arising in the oral cavity, jaw and salivary gland regions of the head and neck, and the melanotic variant of schwannoma.
(Imprint: Nova Medicine and Health)

Preface

Chapter 1. Epithelioid Malignant Peripheral Nerve Sheath Tumors
(Emad Ababneh, MD, and Richard Prayson, MD, MEd, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, US)

Chapter 2. Colonic Perineurioma: A Review of Clinicopathologic Features
(Lanisha D. Fuller, MD, and Richard Prayson, MD, MEd, Department of Anatomic Pathology, Cleveland Clinic, Cleveland, OH, US)

Chapter 3. Peripheral Nerve Sheath Tumors of the Oral Cavity and Jaw
(Bryan B. Hair and Richard A. Prayson, MD, MEd, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH, US, and others)

Chapter 4. Clinicopathologic Features of Salivary Gland Peripheral Nerve Sheath Tumors
(Brigid E. Prayson and Richard A. Prayson, MD, MEd, Ohio State University College of Medicine, Columbus, OH, US, and others)

Chapter 5. Melanotic Schwannomas: A Clinicopathologic Review
(David Sin and Richard A. Prayson, MD, MEd, Case Western Reserve University School of Medicine, Cleveland, OH, US, and others)

Index

Physicians and health care workers, physicians in training, researchers studying peripheral nerve sheath tumors

Peripheral nerve sheath tumors, malignant peripheral nerve sheath tumors, schwannomas, neurofibromas, perineuriomas

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