Naturally Occurring Chemicals for the Treatment and Management of Diabetes Mellitus and Related Disorders

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Ajmer Singh Grewal – Associate Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Geeta Deswal, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Ashwani Kumar Dhingra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Priyanka Kriplani, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Bhawna Chopra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Shikha Baghel Chauhan, PhD – Associate Professor, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000; HEA039050; MED072000
DOI: https://doi.org/10.52305/WBBQ6236

This book represents a comprehensive exploration of the potential of natural compounds derived from plants and marine sources in the battle against the global epidemic of diabetes. Diabetes mellitus, a complex metabolic disorder, continues to rise in prevalence worldwide, necessitating effective treatments and interventions. This book provides a deep understanding of the multifaceted nature of diabetes mellitus, addressing its diverse forms and the intricate factors contributing to its development. It elucidates the chronic hyperglycemia characteristic of diabetes, arising from deficiencies in insulin secretion, action, or both, and the associated symptoms such as excessive thirst, urinary output, and the presence of ketone bodies in the blood or urine, indicating ketoacidosis. Authored by experts from esteemed institutions, the chapters present in-depth insights into the therapeutic potential of phytoconstituents for managing diabetes. Covering herbal products, Thai traditional herbal remedies, marine-based solutions, and various natural compounds, this book explores their roles in mitigating oxidative stress, inflammation and enhancing insulin sensitivity, all with minimal side effects. With a focus on biological properties, mechanisms of action, and clinical applications, this book is an invaluable resource for researchers, clinicians, and anyone interested in diabetes mellitus. It is an essential contribution to the ongoing efforts to understand, prevent, and treat diabetes and its complications. Ultimately, it aims to improve diabetes care and enhance the well-being of individuals affected by this global health challenge.

Table of Contents

Preface
Ajmer Singh Grewal1, Geeta Deswal1, Ashwani K. Dhingra1, Priyanka Kriplani1, Bhawna Chopra1, and Shikha Baghel Chauhan2
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 1. Introduction to Diabetes Mellitus and Its Management
Sangya Dubey1, Janhavi Singh1, Manasvi Saini1, Chaitanay Vinayak Narayan1, Shallu Singh2, Shikha Baghel Chauhan2, Indu Singh2, Harsh Yadav3, and Sachin Gupta3
1I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
2Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
3Department of Pharmacy, Indira Gandhi National Tribal University, Lal Pur, Amarkantak, Madhya Pradesh, India

Chapter 2.
Herbal Products for the Management of Diabetes Mellitus
Raj Kumari1, Meenakshi Sharma1, Sweta Pundir1, Kajal Chaudhary2, Anjali Rajora3, Anjali Nayak4, Paramita Das4, Lakshmi S4, and Sakshi Bharadwaj5
1
I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
2Ram-Eesh Institute of Pharmacy, Knowledge Park-I, Greater Noida, Uttar Pradesh, India
3Lloyd School of Pharmacy, Knowledge Park-II, Greater Noida, Uttar Pradesh, India
4Krupanidhi College of Pharmacy, Chikka Bellandur, Carmelaram, Bengaluru, Karnataka, India
5Life Science Department, Altem Technologies, Bangalore, Karnataka, India

Chapter 3. Thai Traditional Herbal Plants for the Management of Diabetes Mellitus
Jiradej Manosroi1,2, Aranya Manosroi1,2, Charinya Chankhampan1,2, Worapong Kitdamrongtham1,2, Shikha Baghel Chauhan3, and Charu Gupta4
1
North-Chiang Mai University, Chiang Mai, Thailand
2Manose Health and Beauty Research Centre, Chiang Mai, Thailand
3Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
4Amity Institute of Herbal Research & Studies, Amity University, Noida, Uttar Pradesh, India

Chapter 4. Marine-Based Product for the Management of Diabetes Mellitus
Megha Sharma1, Chaitanay Vinayak Narayan2, Avinash Bajpai2, Neelam Singh2, and Janhavi Singh2
1
Metro College of Health Sciences and Research, Greater Noida, Uttar Pradesh, India
2I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India

Chapter 5. Mushrooms in the Management of Diabetes Mellitus
Charu Bharti1, Shalini Jayant2, Neelam Gupta3, Surbhi Gupta2, and Pratibha Dwivedi4
1Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India
2Department of Pharmacology, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India
3I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
4Krishnarpit Institute of Pharmacy, Prayagraj, Uttar Pradesh, India

Chapter 6. Carbohydrates in the Management of Diabetes Mellitus
Fatimah Jan1, Arashdeep Kaur1, Muneeb U. Rehman2, Uditi Handa3, Nazakat Farooq1, Divya Jha4, Vratika Jain4, Arpit Chowdhury4, Shikha Baghel Chauhan4, Indu Singh4
1School of Pharmaceutical Sciences, C.T. University, Ludhiana, Punjab, India
2College of Pharmacy King Saud University, Riyadh, Saudi Arabia
3Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
4Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 7. Glycosides for the Management of Diabetes Mellitus
Fatimah Jan1, Arashdeep Kaur1, Saika Bashir1, Swati Pahwa2, Binu Raina3, Abhimanyu3, Prabhjot Singh Bajwa3, and Kumar Guarve2
1School of Pharmaceutical Sciences, C.T. University, Ludhiana, Punjab, India
2Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
3Ch. Devi Lal College of Pharmacy, Jagadhri, Haryana, India

Chapter 8. Alkaloids in the Management of Diabetes Mellitus
Shikha Kamboj1, Sweta Kamboj1, Rohit Kamboj1, Priyanka Kriplani1, Kumar Guarve1, Sweta Pundir2, Raj Kumari2, Meenakshi Sharma2, and Rohit Malik3
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
3Veer Kunwar College of Pharmacy, Bijnor, Uttar Pradesh, India

Chapter 9.
Phenolic Compounds in the Management of Diabetes Mellitus
Nisham Rani1, Jyoti1, Meena Devi1, Ritu Kataria1, Sangya Dubey2, Chaitanay Vinayak Narayan2, Janhavi Singh2, Sarika Chaudhary3, and Snigdha Bhardwaj2
1G.V.M. College of Pharmacy, Sonepat, Haryana, India
2I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
3One Beat College of Medical Sciences, Sant Garh Nagar, Bhira, Uttar Pradesh, India

Chapter 10. Terpenoids in the Management of Diabetes Mellitus
Anjali Sharma1, Shabnam Faridi2, Devkant Sharma3, and Deepshi Arora1
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2Guru Nanak Institute of Technology, Ambala, Mullana, Haryana, India
3Ch. Devi Lal College of Pharmacy, Jagadhri, Haryana, India

Chapter 11.
The Role of Gingerols in the Management of Diabetes Mellitus
Hemlata Nimesh
Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 12. Organo-Sulphur Compounds for the Management of Diabetes Mellitus
Ritika Singh and Neha Singh
Galgotias College of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh, India

Chapter 13. Steroidal Derivatives in the Management of Diabetes Mellitus
Neha Singh1, Ananya Pandey2, Saumya Das2, and Avijit Mazumder2
1Galgotias College of Pharmacy, Galgotias University, Greater Noida, Uttar Pradesh, India
2Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India

Chapter 14.
Saponins as Potential Therapeutic Agents for Diabetes Mellitus Management
Deepshi Arora1, Manish Kumar2, Yugam Taneja3, Anjali Sharma1, Aakriti Saini1, Diksha Gulati1, and Sharad Visht4
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2School of Pharmaceutical Sciences, C.T. University, Ludhiana, Punjab, India
3Zeon Lifesciences Ltd, Paonta Sahib, Himachal Pradesh, India
4Tishk International University, Erbil, Kurdistan Region, Iraq

Chapter 15 The Role of Catechins in Diabetes and Its Complications
Surbhi Gupta1, Prabhat Singh 2, Vaishali Negi2, and Bhupesh Sharma3
1
Department of Pharmacology, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India
2Faculty of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
3Department of Pharmacology, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 16. The Role of Catechins in Diabetes and Its Complications
Diksha Gulati, Aakriti Saini, Deepshi Arora, and Ashwani K. Dhingra
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 17. Arginine in the Management of Diabetes Mellitus
Neha Singh, Kartikey Panday, Ashish Tiwari, and Pratibha Dwivedi
Krishnarpit Institute of Pharmacy, Prayagraj, Uttar Pradesh, India

Chapter 18. Berberine in the Management of Diabetes Mellitus
Jatin Kumar and Neha Kanojia
Chitkara University School of Pharmacy, Chitkara University, Himachal Pradesh, India

Chapter 19. Charantin: A Promising Natural Compound for the Clinical Management of Diabetes- Exploring Mechanisms, Extraction Process and Clinical Aspects
Jabin T. Paul, Sameer Rastogi, and K.M. Shabana
School of Pharmacy, Noida International University, Greater Noida, G. B. Nagar, Uttar Pradesh, India

Chapter 20. Curcumin in the Management of Diabetes Mellitus
Aakriti Saini1, Diksha Gulati1, Deepshi Arora1, Janhavi Singh2, Sangya Dubey2, Chaitanay Vinayak Narayan2, Neelam Singh2, Gaurav Chaudhary2, Sweta Pundir2, Raj Kumari2, Meenakshi Sharma2, and Rohit Malik3
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
3Veer Kunwar College of Pharmacy, Bijnor, Uttar Pradesh, India

Chapter 21. Gallic Acid in the Management of Diabetes Mellitus
Junaid Tantray1, Akhilesh Patel1, Sourabh Kosey2, Ankur Agrawal3, and Puneet Chauhan1
1NIMS Institute of Pharmacy, NIMS University, Jaipur, Rajasthan, India
2I.S.F. College of Pharmacy, Moga, Punjab, India
3Jai Institute of Pharmaceutical Sciences and Research, Gwalior, Madhya Pradesh, India

Chapter 22. Hesperidin in the Management of Diabetes Mellitus
Neelam Singh1, Chaitanya Vinayak Narayan1, Puneet Gupta2, and Charu Bharti3
1I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
2Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India
3Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

Chapter 23. Kaempferol in the Management of Diabetes Mellitus
Swati Pahwa1, Geeta Deswal1, Neha Saini1, Shivanki Joshi1, Fatimah Jan2, Sonam Grewal3, and Vishakha Saini4
1Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2School of Pharmaceutical Sciences, CT University, Ludhiana, Punjab, India
3M.M. Institute of Pharmacy, M.M. (Deemed to be) University, Mullana, Haryana, India
4Ganpati Institute of Pharmacy, Bilaspur, Yamuna Nagar, Haryana, India

Chapter 24. Quercetin in the Management of Diabetes Mellitus
Meenakshi Sharma1, Raj Kumari1, Rinu Rana2, Dev Raj Sharma2, Sanjay Kumar2, Mahendra Singh Ashawat2, Kalpana Garg3, Gagandeep Kaur4, and Sakshi Bajaj3
1I.T.S. College of Pharmacy, Muradnagar, Ghaziabad, Uttar Pradesh, India
2Laureate Institute of Pharmacy, Kathog, Jawalaji, Himachal Pradesh, India
3Ch. Devi Lal College of Pharmacy, Jagadhri, Haryana, India
4Chitkara University School of Pharmacy, Chitkara University, Himachal Pradesh, India

Chapter 25. Resveratrol in the Management of Diabetes Mellitus
Swati Joshi1, Mahendra Rana1, Satpal Singh Bisht2, Bhuwan Chandra Joshi1, Deepankar Bahuguna3, Amita Joshi Rana1, Meena Devi4, Jyoti4, Nisham Rani4, and Ritu Kataria4
1Department of Pharmaceutical Sciences, Faculty of Technology, Sir J.C. Bose Technical Campus, Kumaun University, Nainital, Uttarakhand, India
2Department of Zoology, D.S.B. Campus, Kumaun University, Nainital, Uttarakhand, India
3Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
4G.V.M. College of Pharmacy, Sonepat, Haryana, India

Chapter 26. Rutin in the Management of Diabetes Mellitus
Jyoti1, Meena Devi1, Nisham Rani1, Ritu Kataria1, Dev Raj Sharma2, Rinu Rana2, Mahendra Singh Ashawat2, Prabhat Singh3, Surbhi Gupta4, and Charu Bharti5
1G.V.M. College of Pharmacy, Sonepat, Haryana, India
2Laureate Institute of Pharmacy, Kathog, Jawalaji, Himachal Pradesh, India
3Faculty of Pharmacy, Swami Vivekanand Subharti University, Meerut, Uttar Pradesh, India
4Department of Pharmacology, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India
5Department of Pharmaceutics, School of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India

Chapter 27. Silymarin in the Management of Diabetes Mellitus
Pravin Kumar1, Shiv Kumar Kushawaha1, Priyanka Chandolia2, and Mahendra Singh Ashawat1
1Laureate Institute of Pharmacy, Kathog, Jawalaji, Himachal Pradesh, India
2
Department of Pharmacology, NIMS Institute of Pharmacy, Jaipur, Rajasthan, India

Chapter 28. Curcumin in Diabetes Management: Nanotechnological Approaches for Bioavailability Improvement
Ashutosh Shukla1, Anupamaa Shukla1, Parjanya Kumar Shukla1, Sanjay Kumar2, Mahendra Singh Ashawat2, Tarun Kumar2, Shavinder Kumari2, Ajay Kumar2, C.P.S. Verma2, Rinu Rana2, and Keshav Dhiman2
1Krishnarpit Institute of Pharmacy, Prayagraj, Uttar Pradesh, India
2Laureate Institute of Pharmacy, Kathog, Jawalaji, Himachal Pradesh, India

Index


Editor’s ORCID iD

Ajmer Singh Grewal: 0000-0002-2418-9616
Geeta Deswal: 0000-0003-3648-0643
Ashwani Kumar Dhingra: 0000-0001-7574-2971
Priyanka Kriplani: 0000-0003-2250-9169
Bhawna Chopra: 0000-0003-2251-2034
Shikha Baghel Chauhan: 0000-0002-1569-213X

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