Natural Products for Treatment of Metabolic Syndrome

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Ajmer Singh Grewal, PhD – Associate Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
Ashwani Kumar Dhingra, PhD – Professor, Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Series: Endocrinology Research and Clinical Developments
BISAC: HEA039160
DOI: https://doi.org/10.52305/FODR8697

Metabolic syndrome (MetS) is a ubiquitous problem that is alarming the world with high prevalence. MetS, also known by other names including syndrome X, insulin resistance syndrome, and dysmetabolic syndrome, constitutes a group of disorders associated with the metabolism of biomolecules and is characterized by hypertension, insulin resistance, cardiovascular diseases, dyslipidaemia, obesity, etc. The pathophysiology of MetS is presumed to involve genetic as well as lifestyle factors including dietary habits, physical activity and perhaps interrupted sleep patterns. The lack of effective prevention and treatment has major effects on the health and lifespan of individuals. As a result, the most challenging task for global researchers is to develop potential lead molecules for the management of MetS with minimal side effects. Weight loss, physical exercise, and healthy diet can help prevent or reverse MetS. A variety of natural compounds are indispensable for the effective management and treatment of MetS. For many years, these natural compounds have provided the basis for development of diverse new classes of potent molecules. This book comprises 6 sections containing 27 chapters written by leading researchers in the field, covering a broad range of topics related to the pathophysiology and possible treatment of MetS with natural products.

Table of Contents

Preface

Chapter 1. Human Metabolite Dysfunction
Sakshi Bhardwaj1, Paramita Das1, Anjali Nayak1 and Ashwani K. Dhingra2
1
Department of Pharmaceutical Chemistry, Krupanidhi College of Pharmacy, Chikkabellandur, Bangalore, India
2Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 2. Epidemiology and Etiology of Metabolic Syndrome
Kajal Nagpal and Deepshi Arora
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Chapter 3. Metabolic Syndrome and Associated Diseases
Preeti Arya1, Abhishek Dabra1, Benu Chaudhary1 and Deepak Singla1
1
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Chapter 4. Natural Products to Treat Metabolic Syndrome
Vimal Arora1, Deepika Bhatia1 and Govind Vyas2
1
University Institute of Pharma Sciences, Chandigarh University, Gharuan, Punjab, India
2R&D and Regulatory Compliance, Inva-Health Inc, Cranbury, New Jersey, U.S.A.

Chapter 5. Management of Metabolic Syndrome: Lifestyle and Dietary Modifications
Nikita Tyagi1, Renu Bala Sharma1, Saloni Arora1 and Shradha Singh1
1
Department of Nutrition and Dietetics, Quantum University, Roorkee, Uttarakhand, India

Chapter 6. Adenosine 5’-Monophosphate (AMP) and GPCR
Shikha Kamboj1, Sunil Kumar1, Vikramjeet Singh1, Rohit Kamboj2 and Sweta Kamboj2
1
Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science & Technology, Hisar, Haryana, India
2Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 7. Targeting Interleukin-18 for Metabolic Syndrome
Harithasree Veerabomma1, Spandana Gollapalli1, Deepankar Bahuguna1, Rahul Kumar2, Pankaj Kumar Singh1, Rupinder Kaur Sodhi3, Jitender Madan1, Shashi Bala Singh2 and Dharmendra Kumar Khatri2
1
Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
2Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
3Chandigarh College of Pharmacy, Mohali, Punjab, India

Chapter 8. Fibroblast Growth Factor-21
Hitesh Malhotra1, Peeyush Kaushik1, Kumar Guarve1, Deepali Tomar2 and Himani Mangl2
1
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2Geeta Institute of Pharmacy, Naultha, Panipat, Haryana, India

Chapter 9. Sodium Glucose Co-Transporter-2
Sanjana Mehta
Chitkara College of Pharmacy, Chitkara University, Punjab, India

Chapter 10. Glucagon-Like Peptide 1
Manish Kaushik1,3, Aditi Kaushik2, Jasmine Chaudhary1 and Akash Jain1
1M. M. College of Pharmacy, M. M. (Deemed to be University), Mullana, Ambala, Haryana
2School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar, Punjab, India
3C. T. Institute of Pharmaceutical Sciences, C. T. Group of Institutions, Jalandhar, Punjab, India

Chapter 11. Lipoprotein Lipase
Gagandeep Kaur1, Vikas Sharma2, Prerna Sharma2 and Nidhi Rani3
1
Chitkara School of Pharmacy, Chitkara University, Himachal Pradesh, India
2Guru Gobind Singh School of Pharmacy, Yamuna Nagar, Haryana, India
3Chitkara College of Pharmacy, Chitkara University, Punjab, India

Chapter 12. Farnesoid X Receptors
Vikas Sharma1, Gagandeep Kaur2, Prerna Sharma1, Deepak Singla1 and Nidhi Rani3
1
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India
2Chitkara University School of Pharmacy, Chitkara University, Himachal Pradesh, India
3Chitkara College of Pharmacy, Chitkara University, Punjab, India

Chapter 13. Peroxisome Proliferator-Activated Receptor Delta
Deepankar Bahuguna1, Chanti Katta Babu1, Vaskuri G. S. Sainaga Jyothi1, Pankaj Kumar Singh1, Shashi Bala Singh2, Rupinder Kaur Sodhi3, Ashish Baldi4 and Jitender Madan1
1Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
2Department of Biological Sciences, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India
3Department of Pharmacology, Chandigarh College of Pharmacy, Mohali (Punjab) India
4Department of Pharmaceutical Science and Technology, Maharaja Ranjit Singh Punjab Technical University, Bathinda, Punjab, India

Chapter 14. Role of Medicinal Plants in Diabetes and Its Complications
Puneet Kaur1, Supriya Agnihotri1 and Rajiv Sharma2
1Chandigarh College of Pharmacy, Landran, Mohali, Punjab, India
2University Institute of Pharma Sciences, Chandigarh University, Mohali, Punjab, India

Chapter 15. Natural Products for the Treatment of Endocrine and Metabolic Disorders
Anjali Saharan1, Rajat Goyal1,2, Sapna Rani3, Shabnam Faridi4, Kashish Wilson2
and Rupesh K. Gautam1
1
MM School of Pharmacy, Maharishi Markandeshwar University, Sadopur-Ambala, Haryana, India
2MM College of Pharmacy, Maharishi Markandeshwar (Deemed To Be  University) Mullana-Ambala, Haryana, India
3Himalyan Institute of Pharmacy, Kala Amb, Himachal Pradesh, India
4 Global Research Institute of Pharmacy, Radaur, Haryana, India

Chapter 16.  Role of Medicinal Plants in the Treatment and Management of Obesity
S. Mohanalakshmi1 and C. K. Ashok Kumar2
1
Amity Institute of Pharmacy, Amity University Madhya Pradesh, Gwalior, Madhya Pradesh, India
2School of Medical and Allied Science, G.D. Goenka University, Gurugram, Haryana, India

Chapter 17. Phytochemicals for Metabolic Syndrome
Vinod Kumar Gauttam1, Kavita Munjal2, Vinita Singh1, Indu Sharma3 and Prinsi Sahpuriya1
1
IES Institute of Pharmacy, IES University Campus, Bhopal, Madhya Pradesh, India
2M.M. College of Pharmacy, Maharishi Markandeshwar (Deemed to be University), Ambala, Haryana, India
3Department of Biotechnology, Maharishi Markandeshwar (Deemed to be University), Ambala, Haryana, India

Chapter 18. Alkaloids: Role in Metabolic Syndrome
Vaibhav Rathi1, Ritu Saini1, Sarika Saini1, Swati Tyagi1 and Smita Narwal2
1
Quantum School of Health Sciences, Roorkee, Uttrakhand, India
2Global Research Institute of Pharmacy, Radaur, Haryana, India

Chapter 19. Role of Phytosterols in Metabolic Syndrome
Madhukar Garg1, Rajwinder Kaur1, Poonam Arora1, Ennus Tajuddin Tamboli2, Charanpreet Singh1 and Lavish Vaid1
1
Chitkara College of Pharmacy, Chitkara University, Punjab, India
2Annasaheb Dange College of B. Pharmacy, Ashta, Maharashtra, India

Chapter 20. Role of Fatty Acids in Metabolic Syndrome Treatment
Manisha Bhatti1, Ankita Sood2 and Rajwinder Kaur2
1
University Institute of Pharma Sciences, Chandigarh University Gharuan, Punjab, India
2Chitkara College of Pharmacy, Chitkara University, Punjab, India

Chapter 21. Phytochemicals for Metabolic Syndrome: Fatty Acids
Meenu Chaudhary1, Praveen Kumar2 and Vaibhav Rathi2
1
School of Pharmaceutical Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India
2Quantum School of Health Sciences, Quantum University, Mandawar-  Roorkee, Uttarakhand, India

Chapter 22. Role of Polysaccharides in Metabolic Syndrome
Ankita Beniwal, Akash Jain and Jasmine Chaudhary
M.M. College of Pharmacy, M.M. (Deemed to be University), Mullana, Ambala, Haryana, India

Chapter 23. Resveratrol: A Phytocentric Overview of Potential in Metabolic Syndrome
Geeta Deswal1, Benu Chaudhary1, Preeti Arya1, Deepak Singla1 and Sonam Grewal2
1
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
2M. M. College of Pharmacy, M. M. Deemed to be University, Mullana, Ambala, Haryana, India

Chapter 24. Role of Curcumin in Metabolic Syndrome
Shikha Baghel Chauhan and Hemlata Nimesh
Department of Pharmaceutics, Amity Institute of Pharmacy, Amity University, Noida, Uttar Pradesh, India

Chapter 25. Natural Glucokinase Activators
Prateek Sharma1, Sukhbir Singh2 and Ajmer Singh Grewal3
1
Government Pharmacy College, Nagrota Bagwa, Kangra, Himachal Pradesh, India
2Chitkara College of Pharmacy, Chitkara University, Punjab, India
3Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India

Chapter 26. Role of Boswellia Species in Metabolic Syndrome
Priyanka Kriplani, Kumar Guarve and Bhawna Chopra
Guru Gobind Singh College of Pharmacy, Yamuna Nagar, Haryana, India

Chapter 27. COVID-19 and Metabolic Syndrome
Deepak Singla1, Benu Chaudhary1, Preeti Arya1, Vikas Sharma1, Prateek Sharma2,3, Lata Rani4
and Peeyush Kaushik1
1
Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India
2Government Pharmacy College, Nagrota Bagwa, Kangra, Himachal Pradesh, India
3Chitkara College of Pharmacy, Chitkara University, Punjab, India
4Chitkara University School of Pharmacy, Chitkara University, Himachal Pradesh, India

Index


Editor’s ORCID iD

Ajmer Singh Grewal – https://orcid.org/0000-0002-2418-9616
Ashwani K. Dhingra –  https://orcid.org/0000-0001-7574-2971