Natriuretic Peptides: Physiology, Molecular Biology, and Clinical Implications


Kailash N. Pandey, PhD (Editor)
Tulane University School of Medicine, LA, USA

Series: Endocrinology Research and Clinical Developments
BISAC: SCI049000

This book provides the current knowledge and recent developments to navigate cellular, molecular, and clinical aspects of natriuretic peptides and their receptors in health and disease. State-of-the-art technology in cell and molecular biology has been applied to delineate the expression, function, and regulation of natriuretic peptides and their receptors both in vitro and in vivo model systems. Transgenic and gene-targeted mouse models have clearly demonstrated that the absence of functional natriuretic peptides and/or their cognate receptors cannot only raise blood pressure but also cause severe hypertensive heart, similar to what is seen in untreated human hypertensive patients. The genetically engineered mouse models have been useful to reveal not only the actual functions of the genes for natriuretic peptides and their receptors, but more critically their modifying interactions with other genes.

This book presents a comprehensive look at the past developments, current status, and future prospects of the natriuretic peptides and their receptor systems in bedside diagnosis, treatments, and therapeutic advancements. The book comprises of fourteen chapters from eminent scientists in their area of research expertise, and presents a wide range of reviews spanning the research works done on the natriuretic peptides and their receptors. Each chapter provides a comprehensive summary covering the aspects of physiology, molecular biology, and clinical implication of the accomplished experimental findings and future perspectives of research to be performed in this vital and important cardiovascular field. It is expected that this book will provide readers a focused overview of the status and perspectives of the natriuretic peptides and their receptors from the past accomplishments to exciting future investigations. (Imprint: Nova)

Table of Contents

Table of Contents


List of Contributors

Chapter 1 – Natriuretic Peptides (pp. 1-30)
Tsuneo Ogawa and Adolfo J. de Bold (Cardiovascular Endocrinology Laboratory, University of Ottawa Heart Institute, Ottawa, Ontario, Canada)

Chapter 2 – Cellular, Molecular and Clinical Aspects of Natriuretic Peptides and Their Receptors in Health and Disease (pp. 31-76)
Kailash N. Pandey (Tulane University School of Medicine, LA, USA)

Chapter 3 – MANP: A Novel Designer Natriuretic Peptide GC-A Activator for the Treatment of Hypertension and Heart Failure (pp. 77-100)
Giuseppe Puccia, Valentina Cannone, Paul M. McKie and John C Burnett Jr. (Cardiorenal Research Laboratory, Division of Cardiovascular Diseases, Mayo Clinic and Foundation, Rochester, MN, USA)

Chapter 4 – Atrial Natriuretic Factor Receptor Guanylate Cyclase: The Journey (pp. 101-118)
Rameshwar K. Sharma and Teresa Duda (Research Divisions of Biochemistry and Molecular Biology, Salus University, Elkins Park, PA)

Chapter 5 – Natriuretic Peptide Receptor: Structure and Signaling Mechanism (pp. 119-136)
Kunio Misono (Reno, Nevada, US)

Chapter 6 – Physiology and Patho-Physiology of Signal Transduction via Cardiac Natriuretic Peptides and Guanylyl Cyclase-A (pp. 137-154)
Ichiro Kishimoto (Department of Endocrinology and Metabolism, National Cerebral and Cardiovascular Center, Japan)

Chapter 7 – Natriuretic Peptide Receptor-C in Physiology and Pathophysiology (pp. 155-174)
Madhu B. Anand-Srivastava (Department of Physiology, Université de Montréal, Quebec, Canada)

Chapter 8 – ARM, the ATP-Regulated Module of ANF-RGC Guanylate Cyclase: Structure and Function (pp. 175-200)
Teresa Duda, Alexandre Pertzev and Rameshwar K. Sharma (The Unit of Regulatory and Molecular Biology, Research Divisions of Biochemistry and Molecular Biology, Salus University, Elkins Park, PA, USA)

Chapter 9 – Natriuretic Peptides: Predictive, Diagnostic and Prognostic Implications in Cardiovascular Diseases with Particular Regard to Acute Cardiovascular Events (pp. 201-216)
Speranza Rubattu and Massimo Volpe (Department of Clinical and Molecular Medicine, School of Medicine and Psychology, Sapienza University of Rome, Sant’Andrea Hospital, Rome, and Neuromed, Pozzilli, Italy)

Chapter 10 – Natriuretic Peptides Receptors: Molecular Biology, Phisiology and Clinical Implication (pp. 217-236)
Daniele Masarone, Raffaella D’Alessandro, Andrea Buono, Rita Gravino, Alessandra Rea, Gemma Salerno, Ernesto Ammendola, Giuseppe Del Giorno, Lucio Santangelo, Antonello D’Andrea, Maria Giovanna Russo, Raffaele Calabrò, Giuseppe Limongelli and Giuseppe Pacileo (Department of Cardiology. Second University of Naples, Naples, Italy)

Chapter 11 – Natriuretic Peptides Modulate Inner Ear Function (pp. 237-258)
George J. Trachte and Janet L. Fitzakerley (Department of Biomedical Sciences, University of Minnesota Medical School, Duluth, MN, USA)

Chapter 12 – Mechanisms of Action of Guanylin Peptides (pp. 259-276)
Aleksandra Sindic (Department of Physiology, School of Medicine, University of Zagreb, Zagreb, Croatia)

Chapter 13 – N-Terminal Pro-B-Type Natriuretic Peptide: A Biomarker of Cardiac Dysfunction during Human Fetal Life (pp. 277-300)
Waltraut M. Merz and Ulrich Gembruch (University Bonn Medical School, Department of Obstetrics and Prenatal Medicine, Bonn, Germany)

Chapter 14 – Transcriptional Control Mechanisms of Guanylyl Cyclase/Natriuretic Peptide Receptor A Gene (pp. 301-330)
Prerna Kumar and Kailash N. Pandey (Tulane University School of Medicine, LA, USA)


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