Nasal High Flow and Non-Invasive Ventilatory Support: Essential Methodology for An Escalation Approach in Respiratory Failure


Antonio M. Esquinas, MD, PhD, FCCP, FAARC – Intensive Care Unit Hospital Morales Meseguer, Murcia, Spain; Director International School of Non-Invasive Ventilation; Director International Non Invasive Ventilation Expert of College
Dimitrios A. Lagonidis, MD, PhD, FCCPPulmonologist-Intensivist, Director of ICU, Critical Care, Pulmonary and Sleep Medicine Services, Giannitsa General Hospital; Giannitsa, Greece
Pedro Silva Santos, MDPulmonology Unit, Centro Hospitalar e Universitário de Coimbra, Hospitais da Universidade de Coimbra, Coimbra, Portugal
Bushra Mina – Pulmonary Critical Care Medicine, Northwell/Lenox Hill Hospital, New York, USA

Series: Pulmonary and Respiratory Diseases and Disorders
BISAC: MED119000; MED079000

There is an important development of non-invasive ventilation and nasal high flow oxygen in patients with hypoxemic respiratory failure, especially due to the high incidence of its use in patients (pandemic, emergency department, intensive care unit). However, there are few descriptions of how these strategies should be implemented and a clear definition of methodology in use. In this book, these treatment options are analyzed, providing the reader with a practical and objective vision of their indications and evaluation of results.

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Table of Contents



Chapter 1. Options and Methodology
Arzu Topeli, MD, MSc
Department of Internal Medicine, Division of Intensive Care, Hacettepe University Faculty of Medicine, Ankara, Turkey

Chapter 2. Physiology
Alexander J. Sweidan, MD, Luqman Nasouf, MD and Catherine S. H. Sassoon, MD
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of California, Irvine, California, USA

Chapter 3. Technology and Devices
Diana Amorim, MD
Pulmonology Department, Leiria Hospital Center, Leiria, Portugal

Chapter 4. Non-Invasive Ventilation: Options and Methodology
Christos Triantafyllou, RN1 and Pavlos Myrianthefs, MD2
1Center for Clinical Epidemiology and Outcomes Research (CLEO), Non-Profit Civil Partnership, Neo Psichiko, Athens, Greece
2National and Kapodistrian University of Athens, School of Health Sciences, Department of Nursing, Papadiamantopoulou, Goudi, Athens, Greece, “Agioi Anargyroi” General Hospital, Nea Kifissia, Greece

Chapter 5. Combined Options of Prone Positioning in Awake Hypoxemic Patients
Giuseppe Fiorentino1, MD, Maurizia Lanza1, MD, Anna Annunziata1, MD and Antonio M. Esquinas2, MD, PhD, FCCP
1Unit of Respiratory Physiopathology, Monaldi Hospital, Naples, Italy
2Intensive Care Unit Hospital Morales Meseguer Murcia, Spain

Chapter 6. Exacerbation in Patients with Nasal Cannula Oxygen Therapy
Héctor Molina Corona1, MD and Vanessa Alejandra Villarreal Vargas2, MD
1Pulmonology Department, Hospital General Fray Junípero Serra, Instituto de Seguridad y Servicios Sociales para Trabajadores del Estado (ISSSTE), Tijuana, B.C. México
2Audiology Department, Centro de la Sordera y el Oído de Tijuana,Tijuana, B.C. México

Chapter 7. Domiciliary Use of High-Flow Nasal Cannula Oxygen Therapy
Margarida Matias, MD
Pulmonology Department, Centro Hospitalar Lisboa Ocidental, Lisboa, Portugal

Chapter 8. Support during Exercise in Chronic Obstructive Pulmonary Disease
Jonathan Cámara Fernandez, MD
Pulmonology Service, Parc Sanitari Sant Joan de Deu, Barcelona, Spain

Chapter 9. Adverse Effects in High-Flow Nasal Cannula Oxygen Therapy
Sara Morgado, MD
Pulmonology Unit Centro Hospitalar De Lisboa Ocidental  Hospitais de Egas Moniz Lisboa, Portugal

Chapter 10. Contraindications for High-Flow Nasal Oxygen Therapy
Nuno Faria1,2, MD and Cláudia Sofia Alves2, MD
1Serviço de Pneumologia, Centro Hospitalar e Universitário do Porto, Porto, Portugal
2Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto, Portugal

Chapter 11. Acute Hypoxemic Respiratory Failure: Pneumonia
Özlem Özkan Kuşcu1 and Ferit Kuşcu2
1Seyhan State Hospital, Intensive Care Unit, Adana, Turkey
2Cukurova University Medical Faculty, Infecitous Diseases and Clinical Microbiology, Adana, Turkey

Chapter 12. Acute Hypoxemic Respiratory Failure Due to COVID-19
Aylin Ozsancak Ugurlu, MD
Department of Pulmonary Medicine, Baskent University, Istanbul, Turkey

Chapter 13. Respiratory Failure in Acute Heart Failure
Stefano Oldani1, MD, Andrea De Vito2, MD, Serena Bensai1, MD and Lara Bertolovic1, MD
1Department of Thoracic Diseases, Pulmonary Operative Unit, Morgagni Pierantoni Hospital, Health Local Agency of Romagna, Forlì, Italy
2Head and Neck Department, ENT Unit, Ravenna – Lugo Hospitals, Health Local Agency of Romagna, Italy

Chapter 14. Respiratory Failure: Non-Invasive Ventilation-Nasal High-Flow Oxygen in Acute Respiratory Distress Syndrome
Mürüvvet Dayıoğlu, MD
Gazi University Medical Faculty, Critical Care Fellowship Program, Ankara, Turkey

Chapter 15. Acute Hypoxemic Respiratory Failure: Interstitial Lung Disease
Filipa Jesus, MD
Pulmonology Department, Unidade Local de Saúde da Guarda E.P.E. Guarda, Portugal

Chapter 16. Mechanical Stretch and Ventilator-Induced Lung Injury Pathophysiology and Clinical Implications in Non-Invasive Ventilation
Marta Duarte-Silva1, MD, João Rodrigues1 MD, Dionisio Maia1, MD and António Miguel1, MD
1Hospital de Santa Marta –Hospital and University Center of Central Lisbon, Lisbon, Portugal

Chapter 17. Do-Not-Intubate in Cancer: Hematologic Malignancy Patients
Yerosimou Fotis, MD, Charatsis Christos, MD and Eirini Papageorgiou, MD
Intensive Care Unit, “Theagenio” Cancer Hospital, Thessaloniki, Greece

Chapter 18. Post Surgical Respiratory Failure (Cardiothoracic Surgery, Abdominal Surgery, Lung Resection)
Erdoğan Duran, MD
Harran University Medical Faculty, Department of Anesthesiology and Reanimation, Şanlıurfa, Turkey

Chapter 19. Acute Hypoxemic Respiratory Failure during Bronchoscopy
Diana Pimenta, MD and Rui Rolo, MD
Pulmonology Department, Braga Hospital, Braga, Portugal

Chapter 20. De-Escalation Therapy in Non-Invasive Ventilatory Approaches: Evidence and Tools for Health Care
Anaura Carrasquel R1, MD, Alexis Jaspe C2, MD and Estefanía Perez M2, MD
1Emergency Department, Ramón y Cajal Hospital, Madrid, Spain
2Unit Intensive Care, Gregorio Marañón Hospital, Madrid, Spain


Editor’s ORCID iD

Antonio M. Esquinas0000-0003-0571-2050

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