Nanotechnology in Modern Medical Imaging and Interventions

Xiaoming Yang (Editor)
Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA

Series: Nanotechnology Science and Technology, Biomedical Devices and their Applications
BISAC: SCI050000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The rapid progress of nanoscience and the application of nanotechnology in medicine are changing the foundations of disease prevention, diagnosis and treatment. At the core of nanotechnology for modern biomedical imaging and interventions, nano/microparticles offer “3-in-1” primary functions as imaging agents, target-specific probes and target-specific therapeutic carriers. Nanoparticle-based imaging and interventions have already exhibited exciting potential in probing the bases or “roots” of diseases, such as to identify their altered molecular profiles and/or cellular characteristics prior to the appearance of visual anatomic alterations. As nanoparticle-based imaging and interventions continue to be refined and are increasingly applied to clinical practice, they will certainly have significant impact on global health care in the near future.

Scientists from various disciplines around the world have already done outstanding work in developing various nanotechnology-based imaging modalities such as molecular and cellular imaging with X-ray-based computerized tomography (CT), ultrasound, magnetic resonance (MR), optics and nuclear medicine. However, clinical applications of these particle-based imaging techniques are still very limited. This can be attributed to a gap existing between basic science and clinical practice, where scientists have no direct access to patient care; meanwhile clinicians are extremely busy with their daily clinical practices and lack the time or means to learn such new technological evolutions. In order to bring the two parties together, a bridge needs to be built between basic science and clinical practice, as termed “translational medicine” by the US National Institute of Health (NIH).

The aim of writing this book is to facilitate such translation of nanotechnology-based imaging modalities from laboratory benches to clinical practices. The authors come from several continents around the world and are experts working in the fields of nanotechnology, material science, biomedical engineering, medicine, pathology, medical imaging and interventional radiology. We hope this book will provoke common interest, brainstorming and cooperation among professionals in both technology and medicine, and will bring nanomedicine one step closer to improving patient care. (Imprint: Nova Biomedical )

Foreword

Preface

SECTION I. OVERVIEW

Chapter 1. Basic Concept of Nanotechnology in Medical Imaging & Interventions
(Xiaoming Yang, University of Washington, WA, USA and others)

Chapter 2. Application of Nanotechnology in Biomedical Imaging
(Erlei Jin and Zhengrong Lu, Case Western Reserve University, OH, USA)

Chapter 3. Application of Nanotechnology in Theranostics
(Francesco Conversano and Sergio Casciaro, National Research Council, Italy)

SECTION II. APPLICATION OF NANOTECHNOLOGY IN MEDICAL IMAGING

Chapter 4. Nanoparticles in Magnetic Resonance Imaging
(Wahajuddin, Isha Taneja and Kanumuri Siva Rama Raju, CSIR- Central Drug Research Institute, India)

Chapter 5. Perfluorocarbon Nanoparticles: A Theranostic Technology for MR Imaging
(Gregory M. Lanza, Shelton D. Caruthers, Anne H. Schmieder, Dipanjan Pan, Grace Hu, Huiying Zhang, Angana Senpan, John S. Allen, Todd Williams, Michael J. Scott, Samuel A. Wickline, Washington University, WA, USA)

Chapter 6. Nanoparticles in Computed Tomography
(Malka Shilo, Menachem Motiei and Rachela Popovtzer, Bar-Ilan University, Israel)

Chapter 7. Micro/Manoparticles in Ultrasound Imaging and Therapy
(Thomas J. Matula and Hong Chen, University of Washington, WA, USA and others)

Chapter 8. Nanoparticles in Fluorescence Optical Imaging
(Mian Chen, Xiaoxiao He, Kemin Wang and Zhen Cheng, Stanford University, CA, USA and others)

SECTION III. APPLICATION OF NANOTECHNOLOGY IN VARIOUS MEDICAL DISCIPLINES

Chapter 9. Image-Guided Cancer Treatment Using Theranostic Nanoparticles
(Minati Satpathy, Hongyu Zhou and Lily Yang, Emory University, GA, USA)

Chapter 10. Nanoparticle-Based Imaging in Gastroenterology
(Jihong Sun, Yajing Zhang and Xiaoming Yang, University of Washington, WA, USA and others)

Chapter 11. Nanoparticle-Based Imaging in Gynecology
(Hongxiu Ji, Overlake Hospital Medical Center and University of Washington, WA, USA)

Chapter 12. Nanoparticle-Based Imaging in Gene/Drug Therapy
(Han Wang, Yanfeng Meng, Feng Zhang and Xiaoming Yang, University of Washington, WA, USA and others)

SECTION IV. APPLICATION OF NANOTECHNOLOGY IN IMAGE-GUIDED INTERVENTIONS

Chapter 13. Interventional Radiology: Historical Perspective and Opportunities for Nanotechnology
(Karim Valji, University of Washington, WA, USA)

Chapter 14. Non-Targeted Nanoparticles in Interventional Radiology
(Siddharth A. Padia, University of Washington, WA, USA)

Chapter 15. Targeted Nanoparticles in Interventional Radiology
(Wayne Monsky, University of Washington, WA, USA)

Chapter 16. Nanoparticle-Mediated Super-Targeted Interventional Oncology
(Xiaoming Yang, University of Washington, WA, USA and others)

Index

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