Na+K+-ATPase: Discovery, Functions and Regulation


Series: Cell Biology Research Progress
BISAC: SCI017000

Sodium–potassium adenosine triphosphatase (Na+/K+-ATPase) is an enzyme located in the plasma membrane of most eukaryotic cells, responsible for maintaining ion concentration gradients against their concentration scale using ATP hydrolysis as a source of energy. The enzyme is involved in many cellular activities, including maintaining cell volume, transporting nutrition, electrical potential, neurotransmission, and any dysfunction or modification of enzyme activity is directly linked to many diseases, such as epilepsy, cardiovascular disease and hypertension, diabetes and other metabolic disorders, digoxin toxicity, fetal abnormalities, neurological disorders, and pulmonary conditions.
In this book, the authors present current research on regulation strategies, Na⁺/K⁺-ATPase as a biomarker in diseased states, and the use of Na⁺/K⁺-ATPase in the physiological and ecological adaptations of insects. Other topics discussed in this compilation include the effects of hormonal and non-hormonal stimulation on Na+/K+-ATPase activity, the physiology and pathophysiology of Na+/K+-ATPase, Na⁺/K⁺-ATPase as a biomarker for energy metabolism and oxidative stress in diseased states, the neurotensin inhibitory effects of [3H]-Ouabain binding to striatal membranes and inversion by administration of clozapine, and Na+/K+-ATPase’s important functional roles in human body.

Table of Contents

Table of Contents


Chapter 1. Effect of Glutathionlyation, Hormonal and Non-Hormonal Stimulation on Na+/K+-ATPases Activity
(Nasma D. Eljack, Department of Chemistry, Turabah University College, Taif University, Kingdom of Saudi Arabia; Department of Chemistry, Faculty of Science, University of Khartoum Kingdom of Saudi Arabia)

Chapter 2. Physiology and Pathophysiology of Na+/K+-ATPase
(Adel Q. Alkhedaide, Clinical Laboratory Department, Turabah University College, Taif University, Taif, Saudi Arabia)

Chapter 3. Na⁺/K⁺-ATPase as a Biomarker for Energy Metabolism and Oxidative Stress in Diseased States
(David Calderón Guzmán, Hugo Juárez Olguín, Maribel Ortiz Herrera, Quetzalli Veloz Corona and Francisca Trujillo Jiménez, Laboratory of Neuroscience, Instituto Nacional de Pediatría, Mexico City, Mexico, and others)

Chapter 4. Neurotensin Inhibitory Effect on [3H]-Ouabain Binding to Striatal Membranes Is Inverted by Administration of Clozapine
(Carina Rosin, Victoria Wies, María Graciela López Ordieres, Georgina Rodríguez de Lores Arnaiz, Instituto de Biología Celular y Neurociencias “Prof. E. De Robertis”, Universidad de Buenos Aires, Buenos Aires, Argentina, and others)

Chapter 5. Na+/K+-ATPase: Important Functional Roles in the Human Body
(Mohammed A. A. Khalid, Department of Chemistry, Turabah University College, Taif University, Turabah, Saudi Arabia, and others)

Chapter 6. Role of Na+/K+-ATPases in the Physiological and Ecological Adaptations of Insects
(C. C. Sheeja, Maxwell Beyline and Lekha Divya, Department of Animal Science, Godavari Building, Tejaswini Hills, Periya, Kasaragod, Kerala, India)


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