Myostatin: Structure, Role in Muscle Development and Health Implications


Dolores Christensen (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

Myostatin, also known as growth and differentiation factor-8, is a member of the TGF-â family member and is mainly produced by skeletal muscle. Myostatin circulates in the serum in a latent form, whereas it acts almost exclusively on skeletal muscle. Chapter One of this book discusses the role of myostatin and related factors in muscle hypertrophy and atophy. Chapter Two concentrates on specific alterations of positive and negative regulators of muscle mass in patients with chronic kidney disease. Chapter Three examines the potential benefits of the myostatin gene polymorphisms in livestock animals. Chapter Four studies myostatin functions in fish. (Imprint: Novinka)

Table of Contents

Table of Contents


Chapter 1. The Role of Myostatin and Related Factors in Muscle Hypertrophy and Atrophy
Kunihiro Tsuchida, Keisuke Hitachi, Masashi Nakatani, Akiyoshi Uezumi, and Hiroshi Ageta (Division for Therapies against Intractable Diseases, Institute for Comprehensive Medical Science (ICMS), Fujita Health University, Toyoake, Japan)

Chapter 2. Myostatin and the Balance between Positive and Negative Regulators of Muscle Mass in Patients with Chronic Kidney Disease
Francesca Ansaldo, Daniela Picciotto, Francesca Viazzi, Samantha Milanesi, Giacomo Garibotto, and Daniela Verzola (Department of Internal Medicine, Nephrology Division, Genoa University amd IRCCS AOU San Martino-IST, Genoa, Italy)

Chapter 3. The Potential Benefits of Myostatin Gene (MSTN) Polymorphisms in Livestock Animals
Agnieszka Magdalena Markowska (Dublin, Ireland)

Chapter 4. A Muscle-Tissue Culture System to Study Myostatin Function in Fish
Julia Torres-Velarde, Eric Bautista-Guerrero, Itzel Sifuentes-Romero, Teresa García-Gasca, and Alejandra García-Gasca (Laboratory of Molecular Biology and Tissue Culture of Aquatic Organisms, Centro de Investigación en Alimentación y Desarrollo, Mazatlán, Sinaloa, Mexico, and others)


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