Multiple Myeloma: Risk Factors, Diagnosis and Treatments

Steve Holt (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Multiple myeloma (MM) is a hematological malignancy characterized by the clonal expansion of monoclonal immunoglobulin-secreting plasma cells in the bone marrow (BM). Multiple myeloma is associated with lytic bone lesions, anemia, immunodeficiency and renal impairment. Multiple myeloma accounts for more than 10% of all hematologic malignancies and about 1% of all cancers.

Multiple myeloma remains mostly incurable despite conventional intensive high dose chemotherapy followed by hematopoietic stem cell transplant. The costs associated with multiple myeloma are among the highest. This book discusses the diagnosis of multiple myeloma along with the risk factors involved and the treatments that are available. (Imprint: Nova Biomedical )

Preface

Chapter 1 - Recent Advances in Diagnosis and Treatment of Multiple Myeloma 1
Drew Dill, MD, Mansoor Ul Haq, MD and Daruka Mahadevan, MD PhD (The West Cancer Center/University of Tennessee Health Sciences Center, Memphis, TN, USA)

Chapter 2 - Development of Proteasome Inhibitors for the Treatment of Multiple Myeloma 49
Ota Fuchs (Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 3 - Cereblon As the Cellular Target Responsible for the Anti-Multiple Myeloma Activity of Immunomodulatory Drugs (Thalidomide, Lenalidomide and Pomalidomide) 81
Radka Bokorova, Jaroslav Polak, Martin Vostry, Arnost Kostecka and Ota Fuchs (Institute of Hematology and Blood Transfusion, Prague, Czech Republic)

Chapter 4 - Review of Risk Factors, Diagnosis Criteria and Treatment in Multiple Myeloma 101
Elena Flores-Ballester and Julio Garcia-Suárez (Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid)

Chapter 5 - Diagnosis and Management of Oral Manifestations of Multiple Myeloma 111
Annie Karoline de Oliveira Tanaka, Gustavo Zanna Ferreira, Fábio Luiz Coracin and Paulo Sérgio da Silva Santos (Stomatology Department of Bauru School of Dentistry - University of São Paulo, Bauru, SP, Brazil, and others)

Chapter 6 - New Drugs and New Strategies for the Treatment of Multiple Myeloma Patients 119
A. Reale, A. Melaccio, R. Ria and A. Vacca (Department of Biomedical Sciences and Human Oncology, Section of Internal Medicine and Clinical Oncology)

Chapter 7 - The Role of DNA Methylation in the Genetics and Epigenetics of Multiple Myeloma 147
Hiroshi Yasui, Tadao Ishida and Kohzoh Imai (Center for Antibody and Vaccine, Research Hospital, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan, and others)
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Chapter 8 - Bisphosphonate Related Osteonecrosis of the Jaw in Multiple Myeloma 157
Kang-Min Ahn DDS, MSD, PhD (Associate professor, Department of oral and maxillofacial surgery, College of Medicine, University of Ulsan Seoul, South Korea)

Chapter 9 - The Mechanism of Action of Novel Antimyeloma Agents and Newer Therapeutic Strategies 179
Yossi Cohen (Institute of Hematology, Asaf Harofhe University Hospital, Zerifin, Israel, and others)
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Index 237

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