Motor Neuron Diseases: Causes, Classification and Treatments

Bradley J. Turner (Editor)
Neurodegeneration Division, The Florey Institute of Neuroscience, University of Melbourne, Australia

Julie B. Atkin (Editor)
Department of Biochemistry, La Trobe University, Bundoora Victoria, Australia

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: MED056000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Motor neuron disease (MND), also commonly known as amyotrophic lateral sclerosis (ALS), is a chronic neurodegenerative disorder of the motor system in adults, characterized by the loss of motor neurons in the cortex, brain stem and spinal cord. This book presents current research from across the globe in the study of the causes, classification and treatments of MND, including membrane trafficking defects as determinants of motor neuron susceptibility and degeneration in ALS; motorneurons specific calcium dysregulation and perturbed cellular calcium homeostasis in ALS; stem cells and their application in ALS treatment; excitotoxicity and selective motor neuron degeneration and therapeutic intervention and assistive technology treatments. (Imprint: Nova Biomedical )

Preface

Chapter 1. Motor Neuron Disease: Causes, Classification and Treatments
Louisa Ng and Fary Khan (Neurological Rehabilitation Physician, Royal Melbourne Hospital, Melbourne VIC, Australia and Department of Rehabilitation Medicine, University of Melbourne, Australia)
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Chapter 2. Membrane Trafficking Defects as Determinants of Motor Neuron Susceptibility and Degeneration in ALS
Bradley J. Turner (Florey Neuroscience Institute and Centre for Neuroscience, University of Melbourne, Victoria, Australia) and Julie D. Atkin (Florey Neuroscience Institute and Centre for Neuroscience, University of Melbourne, Victoria, Australia and Department of Biochemistry, LaTrobe Institute of Molecular Science, La Trobe University, Victoria, Australia)

Chapter 3. Motoneuron Specific Calcium Dysregulation and Perturbed Cellular Calcium Homestasis in Amyotrophic Lateral Sclerosis: Recent Advances Gained from Genetically Modified Animals and Cell Culture Models
Manoj Kumar Jaiswal (McGovern Institute for Brain Research, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA)

Chapter 4. Treatment of ALS Utilizing a Stem Cell Strategy
Xiufang Guo (Hybrid Systems Laboratory, NanoScience Technology Center, University of Central Florida, Orlando, Florida, USA) and James J. Hickman (Hybrid Systems Laboratory, NanoScience Technology Center, University of Central Florida, Orlando, Florida, USA and College of Medicine, University of Central Florida, Orlando, FL, USA)

Chapter 5. TDP-43-Immunoreactive Pathology in Frontotemporal Lobar Degeneration with TDP Proteinopathy (FTLD-TDP) With and Without Associated Motor Neuron Disease (MND)
R. A. Armstrong (Vision Sciences, Aston University, Birmingham, UK)

Chapter 6. Excitotoxicity and Selective Motor Neuron Degeneration
K. A. Staats and L. Van Den Bosch (Department of Neurobiology, K.U. Leuven, Belgium and Vesalius Research Center, VIB, Belgium)

Chapter 7. Stem Cell Application in Amyotrophic Lateral Sclerosis: Growth Factor Delivery and Cell Therapy
Ksenija Bernau, Michael G. Meyer and Masatoshi Suzuki (Department of Biomedical Engineering and Department of Comparative Biosciences, University of Wisconsin-Madison, Madison, Wisconsin, USA and The Stem Cell and Regenerative Medicine Center, University of Wisconsin-Madison, Madison, WI, USA)

Chapter 8. Therapeutic Intervention in Spinal and Bulbar Muscular Atrophy (SBMA)
Haruhiko Banno, Masahisa Katsuno, Keisuke Suzuki and Gen Sobue (Department of Neurology, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan and Institute for Advanced Research, Nagoya University, Nagoya, Japan)

Chapter 9. Expert Commentary: Motor Neuron Disease: Assistive Technology
Louisa Ng and Fary Khan (Neurological Rehabilitation Physician, Royal Melbourne Hospital, Melbourne VIC, Australia and Department of Rehabilitation Medicine, University of Melbourne, Australia)

Chapter 10. Comparative Study on Application of Invasive and Non-Invasive Ventilation to ALS Patients in Japan, the USA and Europe
Rika Yamauchi, Jun Kawamata and Shun Shimohama (Department of Neurology, School of Medicine, Sapporo Medical University, Japan)
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Chapter 11. Motor Speech Disorder in Patients with Motor Neuron Disease: How to Estimate and Manage their Disturbed Speech Sounds Clinically
Hideto Saigusa (Department of Otolaryngology, Nippon Medical School, Tokyo, Japan)

Index

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