Monitoring of Antidepressant Therapy by Using Heart Rate Variability

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Thomas Kibbel (Editor)
Universitatsklinikum Schelswig-Holstein, Lubek, Germany

Series: Cardiology Research and Clinical Developments, Pharmacology – Research, Safety Testing and Regulation
BISAC: MED000000

The cardiac autonomic nervous system is typically impaired in patients with major depression and panic disorder. And furthermore, this unfavorable condition will be dosed dependent intensified by antidepressant drugs. This increases the cardiovascular risk and can be estimated by analysis of heart rate variability (HRV), currently and non-invasively.

The reduction of HRV is less expressed by SSRI than by TCA. The parasympathetic determinated components of HRV are in therapeutic doses more impaired than the rather sympathetic determinated components. This reduction is dependent on plasma concentration. This new book discusses sufficient information which suggests that HRV influences are agent specific, as well as how therapies can be better monitored in the future. (Imprint: Nova Biomedical)

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Table of Contents

Table of Contents

ABSTRACT

1. INTRODUCTION – NEW OPPORTUNITIES FOR ESTIMATION OF CARDIOVASCULAR SIDE EFFECTS IN ANTIDEPRESSANT THERAPY

2. SIDE EFFECTS OF ANTIDEPRESSANT DRUGS – SEVERE IMPAIRMENT IN OVERDOSE

3. DEPRESSION, ANTIDEPRESSANT THERAPY AND AUTONOMIC NERVOUS SYSTEM – ASSOCIATION WITH CARDIAC DISORDERS

4. AUTONOMIC NERVOUS SYSTEM, HEART RATE VARIABILITY (HRV) AND PROGNOSIS – PRINCIPLES OF HRV

5. DEPRESSION, ANTIDEPRESSANT THERAPY AND HEART RATE VARIABILITY – SYNOPSIS OF THE LITERATURE

6. INTOXICATION WITH ANTIDEPRESSANT DRUGS – MECHANISMS OF CARDIAC IMPAIRMENT

7. CHANGES OF HEART RATE VARIABILITY IN TCA INTOXICATION – DETAILED INFORMATION ON DOXEPIN

8. RISK OF HIGHER INCIDENCE OF ARRHYTHMIC EVENTS IN DOXEPIN OVERDOSE – DIFFERENTIATION OF HRV MINIMUM AND LF/HF INCREASE

9. ARRHYTHMIC EVENTS AND SYMPATHOVAGAL BALANCE – CORRELATION OF ARRHYTHMIC INCIDENCE AND LF/HF INCREASE

10. HRV ANALYSIS IN TIME COURSE AND PHASE DEPENDENT SIDE EFFECTS – CHANGES OF BLOOD PRESSURE AND HEART RATE IN RELATION TO HRV

11. METHODICAL LIMITATIONS OF HRV – PARTIALLY CONTRARY RESULTS CAUSED BY THE LACK OF CONSENSUS

12. HRV ANALYSIS IN ANTIDEPRESSANT THERAPY – IMPORTANCE AND PERSPECTIVES

13. CONCLUSION – HRV FOR NON-INVASIVE IMPROVEMENT OF ANTIDEPRESSANT MONITORING

REFERENCES

INDEX

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