Molecular Signaling of Mammalian Inner Ear Development

Dorothy A. Frenz (Editor)
New York Medical College, Department of Cell Biology and Anatomy, Valhalla, NY, USA

Series: Human Anatomy and Physiology, Otolaryngology Research Advances
BISAC: SCI008000

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Volume 10

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Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The inner ear originates from an ectodermal thickening, the otic placode, which lies adjacent to the developing hindbrain. Complex interactions between regulatory signaling molecules guide development of the simple otic placode into the elaborate, multifunctional organs of hearing and balance. This book delves into recent research in the field, focusing on successive stages of inner ear development and how they are influenced by the coordinate activity of signaling molecules.

This book begins with an overview of the evolutionary adaptation of the organ of Corti (organ of hearing) and the molecular signals that characterize ancestral development of the inner ear. Following this, the topics addressed include the complex signaling interactions underlying induction of the otic placode, key molecular mediators influencing inner ear development and patterning, genetic signaling of the vestibular (balance) system and clinical correlations to human balance disorders, commitment to auditory hair cell fate, and reliance of the inner ear on retinoic acid, a biologically-active derivative of vitamin A, for appropriate development. This timely and comprehensive book provides an excellent resource for researchers, clinician-scientists and students alike. (Imprint: Nova Biomedical )

Preface

Chapter 1. Evolution of the Mammalian Auditory System: An Integrated Perspective of the Molecular Development
(Ning Pan, Israt Jahan, Karen Elliott, Jennifer Kersigo and Bernd Fritzsch, University of Iowa)

Chapter 2. Induction and Morphogenesis of the Inner Ear
(Bruce B. Riley, Texas A&M University, TX, USA)
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Chapter 3. Function and Regulation of Fibroblast Growth Factors in the Developing Otic Epithelium
(Androulla Economou and Mark Maconochie, University of Sussex, UK)

Chapter 4. BMP Signaling during Inner Ear Development
(E. Bryan Crenshaw III, The Children’s Hospital of Philadelphia, PA, USA, and others)

Chapter 5. Role of Hedgehog and Wnt Signaling in Mammalian Inner Ear Formation
(Jinwoong Bok, Yonsei University College of Medicine, Seoul, Korea)

Chapter 6. Genetic Signal Pathways that Control the Development of the Vestibular System and Clinical Correlates in Patients with Balance Disorders
(Thomas R. Van De Water, Suhrud Rajguru and Hinrich Staecker, University of Miami Miller School of Medicine, FL, USA, and others)

Chapter 7. Determination of Hair Cell Fate in the Cochlea: Molecular Signaling Pathways
(Matthew W. Kelley, Laboratory of Cochlear Development, NIDCD, NIH, MD, USA)

Chapter 8. Retinoic Acid Signaling in the Developing Otocyst
(Dorothy A. Frenz and Mark K. Maconochie, New York Medical College, NY, USA, and others)

Index

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