Modulation of the Development of Morphine Antinociceptive Tolerance by Endoplasmic Reticulum Chaperones

Tomohiko Aoe
Department of Anesthesiology, Chiba University Graduate School of Medicine

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000

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Volume 10

Issue 1

Volume 2

Volume 3

Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Opioids are potent analgesics that are widely used to control acute and chronic pain. While repeated administration of opioids, particularly morphine, induces tolerance that reduces the effectiveness of the analgesic, the precise molecular mechanism for the development of tolerance remains uncertain. This book will discuss a new aspect of a molecular mechanism for the development of opioid tolerance. (Imprint: Nova)

Preface

Introduction

Experimental Studies

Conclusion

Acknowledgment

Index

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