Table of Contents
Table of Contents
Preface
Introduction
Experimental Studies
Conclusion
Acknowledgment
Index
Modulation of the Development of Morphine Antinociceptive Tolerance by Endoplasmic Reticulum Chaperones
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Tomohiko Aoe
Department of Anesthesiology, Chiba University Graduate School of Medicine
Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED071000
Opioids are potent analgesics that are widely used to control acute and chronic pain. While repeated administration of opioids, particularly morphine, induces tolerance that reduces the effectiveness of the analgesic, the precise molecular mechanism for the development of tolerance remains uncertain. This book will discuss a new aspect of a molecular mechanism for the development of opioid tolerance. (Imprint: Nova)
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