Amr Kamel Khalil Ahmed, MD – Public Health Department, Riyadh First Health Cluster, Ministry of Health Kingdom of Saudi Arabia
Maher Monir Akl – Faculty of Medicine, Novosibirsk State University, Russia; Faculty of Science, Mansoura University, Egypt; Department of Chemistry, Faculty of Science, Mansoura University Mansoura, Egypt

Series: Metabolic Diseases – Laboratory and Clinical Research
BISAC: SOC057000; MED027000; MED067000
DOI: https://doi.org/10.52305/TZNF4201

This book introduces a groundbreaking scientific paradigm that redefines the origins and classifications of chronic diseases through the lens of mitochondrial dysfunction. This pioneering volume proposes that the collapse of mitochondrial bioenergetics, not merely genetic mutations or localized pathology, is the central driver behind a broad spectrum of modern illnesses.

Across five chapters, the book systematically unifies gastrointestinal disorders, neurological diseases, musculoskeletal conditions, renal failure, and cancer within a cohesive metabolic framework. From the Systemic Digestive Dysregulation Syndrome (SDDS) that reinterprets diabetes and gut cancers, to the Neuroenergetic Collapse Framework linking migraine, Alzheimer’s disease, and glioblastoma, each chapter reveals how mitochondrial suffocation underpins seemingly unrelated pathologies. Additional chapters explore novel models such as the Mitochondrial Calcification Disorder (MMCD), the Bioelectric Kidney Recharge Hypothesis (BKR), and the Muscular Mitochondrial Suffocation Syndrome (MMSS), each offering new diagnostic and therapeutic pathways grounded in energy metabolism.

By transcending the traditional organ-based disease model, this book calls for a new era of “Mitochondrial Medicine” focused on restoring mitochondrial function, redox balance, and metabolic resilience. It is an essential contribution for clinicians, researchers, and health innovators seeking to understand the unifying molecular roots of chronic disease and to pioneer interventions that intercept illness at its source rather than merely treating symptoms.