MicroRNA let-7: Role in Human Diseases and Drug Discovery

Neetu Dahiya (Editor)
University of Virginia, Charlottesville

Series: DNA and RNA: Properties and Modifications, Functions and Interactions, Recombination and Applications, Genetics – Research and Issues
BISAC: MED071000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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MicroRNAs are small non-coding RNAs involved in posttranscriptional regulation of gene expression. Thousands of miRNAs have been identified in different organisms including viruses, insects, plants and animals. MiRNAs has emerged as key regulators of important biological processes. The differential expression of miRNAs in various human diseases has made them potential candidates for developing novel therapies and personalized medicines. This book is focused on microRNA let-7, the second miRNA discovered in the year 2000 and one of the most studied miRNA. This book discusses various aspects of miRNA let-7 starting from its discovery, biogenesis, transcriptional and posttranscriptional regulation to its crucial role in various fundamental cellular processes such as development, stem cell maintenance and differentiation, regulation of signaling pathways in cancer, drug resistance and therapeutic potential in different human diseases. (Imprint: Nova Biomedical )

Preface

Chapter 1. MicroRNA let-7: Discovery, Biogenesis, and General Function
(Cheng-Chia Yu)

Chapter 2. Transcriptional and post-transcriptional regulation of let-7
(Monika Sangwan, Neetu Dahiya)

Chapter 3. Let-7 and signaling pathways in cancers
(Yuanjia Tang, Nan Shen)

Chapter 4. Role of let-7 networks in stem cell maintenance and differentiation
(Candida Vaz, Vivek Tanavde)
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Chapter 5. The role of microRNA let-7 in stem/progenitor cells
(Shao-Chih Chiu, Shinn-Zong Lin)

Chapter 6. The impact of the let-7 family on resistance to anticancer treatment
(Mathias Fritz, Damian J. Hussey, Joerg Haier, Richard.Hummel)

Chapter 7. Therapeutic Potential of miRNA let-7 in Human Diseases
(Lu Elean Wang, Xu-Hui Li, Zhi Rong Qian)

Chapter 8. Let-7 and Cancer
(Cesar Seigi Fuziwara, Murilo Vieira Geraldo and Edna Teruko Kimura)

Chapter 9. Roles of let-7 family miRNAs in development and differentiation
(Rikako Sanuki, Takahisa Furukawa)
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Index

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