Microglia: Physiology, Regulation and Health Implications


Erica R. Giffard (Editor)

Series: Neuroscience Research Progress
BISAC: SCI089000

Microglia are the resident brain immune cells of the central nervous system (CNS). These glial cells have an essential role in the CNS development and homeostasis, as well as in several diseases through the production of proinflammatory cytokines, trophic factors and reactive oxygen species, among other elements. Microglia cells are one of the most intrinsically plastic cell types of the human body, possessing the ability to assume different morphologies and molecular properties in response to their rapid-changing surroundings. This book discusses the physiology, regulation and health implications of microglia. (Imprint: Nova Biomedical)

Table of Contents

Table of Contents


Chapter 1 – Microglia: A Double-Edged Sword for Alzheimer‟s Disease (pp. 1-66)
J. Guedes, A. T. Viegas, M. C. Pedroso de Lima and A. L. Cardoso (Doctoral Programme in Experimental Biology and Biomedicine, CNC – Center for Neuroscience and Cell Biology, University of Coimbra, Coimbra, Portugal, and others)

Chapter 2 – New Insights in the Pro- and Anti-Neurogenic Interventions of Microglia and Their Association to Gliomas (pp. 67-112)
Dora Brites, Cátia Gomes, Rui Pinheiro and Ana Sofia Falcão (Research Institute for Medicines (iMed.ULisboa), Faculdade de Farmácia, Universidade de Lisboa, Avenida Professor Gama Pinto, Lisbon, Portugal, and others)

Chapter 3 – The Diversity of Microglial Activators and Their Elicited Responses: Implications for Central Nervous System Functions (pp. 113-156)
Stephanie M. Schindler, Lindsay J. Spielman, Ekta Bajwa, Wyatt T. Slattery, Darlene B. Harris and Andis Klegeris (Department of Biology, University of British Columbia Okanagan Campus, Kelowna, British Columbia, Canada, and others)

Chapter 4 – The Interplay of Protein Aggregates, Microglia and Neuroinflammation in Neurodegenerative Disease (pp. 157-204)
Sharon C. Hook, Kate Roberts, Janet R. Kumita and Justin J. Yerbury (Illawarra Health and Medical Research Institute, Wollongong, Australia, and others)

Chapter 5 – The Role of Microglial Galectin-3 in Central Nervous System Disease (pp. 205-216)
Masayuki Niwa, Takashi MaruYama, Kenji Hisamatsu, Kazuhiro Kobayashi, Tatsuhiko Miyazaki, Akihiro Hirata, Yuichiro Hatano, Hiroyuki Tomita and Akira Hara (Medical Science Division, United Graduate School of Drug Discovery and Medical Information Sciences, Gifu University, Gifu, Japan, and others)

Chapter 6 – Role of Microglia in Neurological Manifestations of HIV-1 and HTLV-1 (pp. 217-240)
Tashema N. Edwards and Jean-Pierre Louboutin (Faculty of Medical Sciences, University of West Indies, Kingston, Jamaica, and others)


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