Microarrays: Principles, Applications and Technologies


James V. Rogers, PhD (Editor)
Center for Life Sciences Research, Springfield, Ohio, USA

Series: Genetics – Research and Issues
BISAC: MED107000

The sequencing of the human genome was a pivotal event in science that opened the door to exploring the structure and function of genes and their regulation. The activation or suppression of transcribed genes is critical to the orchestration of everyday biological processes at the cellular, tissue, and physiological levels. The rapid advance of science and technology has yielded the development of the microarray technique, which has propelled a much deeper understanding of the genome.

By combining these technological advances in microarrays with statistical and bioinformatics software, investigators are now able to perform scientific investigations geared towards answering unique biological problems that encompass many fields of research from genetics and evolution to molecular medicine, health, and disease. This book provides an overview of the use and application of microarrays throughout the life sciences to address diverse complex biological questions. In this collection, authors present information on using microarrays to unlock molecular mechanisms and gene expression patterns associated with research areas ranging from biodefense, pathological changes, and monitoring antimicrobial resistance genes to diagnostics, marine biodiversity, and dermal toxicology. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1. Microarray Technology for Category ‘A’ Bioterrorism Agent Research: Current Status and Perspectives
(Lauren Huettner and Eric M. Vela, Division of Veterinary Public Health, College of Public Health, The Ohio State University, Columbus, Ohio, USA and others)

Chapter 2. Similarity Threshold Selection Tools for Gene Co-Expression Networks
(Liliana López-Kleine and Luis Guillermo Leal, Department of Statistics, Universidad Nacional de Colombia – Sede Bogotá, Columbia)

Chapter 3. Mining Gene Expression Microarrays for Long Non-Coding RNAs
(L. Zhang, D.R. Wagner and Y. Devaux, Laboratory of Cardiovascular Research, Centre de Recherche Public de la Santé, Luxembourg, Luxembourg and others)

Chapter 4. An In Situ Electroporation and Flow Device for Mechanotransduction Studies
(Zoltán Kis, Leila Towhidi, Henry Ip, Emmanuel Drakakis, Anil Bharath and Rob Krams, Imperial College London, London, United Kingdom)

Chapter 5. A New Application for Microarrays: Analysis of Global MicroRNA Expression Profiles in the Extracellular Microvesicles of Human Macrophage-Like Cells
(Tadayoshi Kagiya and Masayuki Taira, Iwate Medical University, Iwate, Japan)

Chapter 6. Identification of Reference Genes by Meta-Microarray Analyses
(Issac H.K. Too, Sean S.J. Heng, Oliver Y.W. Chan, Bryan M.H. Keng, Ching-Yee Chia, Claudia W.X. Lim, Wan-Ting Leong, Qinghao Chu, Ernest J.G. Ang, Yongjie Lin and Maurice H.T. Ling, Department of Biological Sciences, National University of Singapore, Singapore and others)

Chapter 7. Invertebrate DNA Chip: Opportunities and Challenges in the Development and Application of Microarrays for Marine Biodiversity Studies
(Srujana Chitipothu, Alessia Cariani, Fabio Bertasi, Marco Stagioni, Marc Kochzius, Dietmar Blohm, Fausto Tinti and Monica Landi, Centre for Applied Gene Sensor Technology (CAG), FB2-UFT, University of Bremen, Bremen, Germany and others)

Chapter 8. Using Microarrays to Decipher the Virus-Host Interactions in HCV Infected Patients: Implications for Viral Resistance, Drug Development and Personalized Medicine
(Jing Sun, Jianguo Yuan, Bing Liu, Shilin Li, Yujia Li, Xiaoqiong Duan, Chunhui Yang, Peibing Zeng and Limin Chen, Sichuan Mingri Pharmaceutical Research Institute of New Technology, Chengdu, Sichuan, China and others)

Chapter 9. Microarray Diagnostics for Orthopoxviruses, Filoviruses, Arenaviruses and Type A Influenza Virus
(Alexander N. Sinyakov and Vladimir A. Ryabinin, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia)

Chapter 10. Using DNA Microarray Technology to Monitor the Distribution of Antimicrobial Resistance Genes in <i>Escherichia Coli</i> Isolated from Animal Colibacillosis Outbreaks
(Pietro Badagliacca, Luke Masson, Alfreda Tonelli, Giacomo Migliorati and Josée Harel, Istituto Zooprofilattico Sperimentale dell’Abruzzo e del Molise “G. Caporale”, Campo Boario, Teramo, Italy and others)

Chapter 11. Phenotypic Anchoring of Liver Injury in Rats by Gene Expression Profiling
(Minjun Chen, Reagan Kelly, Lillian Tong, Jürgen Borlak and Weida Tong, Division of Bioinformatics and Biostatistics, FDA’s National Center for Toxicological Research, Jefferson, Arkansas, USA and others)

Chapter 12. Application of Microarray Technology in Toxicology
(Abir T. El-Alfy, Department of Pharmaceutical Sciences, College of Pharmacy, Chicago State University, Chicago, Illinois, USA)

Chapter 13. Microarray Analysis of Gene Transcription Profiles in Chronic Rhinosinusitis
(Marcin Fraczek, Beata Rostkowska-Nadolska and Malgorzata Kapral, Department of Otolaryngology, Wroclaw Medical University, Wroclaw, Poland and others)

Chapter 14. Transcriptomic Analysis of Oligomeric Amyloid-β Treated Primary Cortical Neurons Reveals Dysregulation of Genes Involved in the Biosynthesis of Steroids and Cholesterol
(Bilal Malik, Cathy Fernandes, Richard Killick, Alessia Usardi, Ritchie Williamson, Stuart Kellie, Brian H. Anderton and C. Hugh Reynolds, King’s College London, Department of Neuroscience, Institute of Psychiatry, De Crespigny Park, Denmark Hill, London SE5 8AF, UK and others)

Chapter 15. Application of Microarrays to Cutaneous Chemical Exposures
(James V. Rogers and Jennifer A. Price, Battelle, Biomedical Research Center, Columbus, Ohio)


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