Methylenetetrahydrofolate Reductase (MTHFR) in Health and Disease

Roger Evans (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

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Methylenetetrahydrofolate Reductase (MTHFR) is a key enzyme involved in the folate pathway. Folate, a water soluble B vitamin, naturally present in fruits and vegetables, is a critical methyl donor for several molecular pathways necessary for cellular replication and maintenance.

The authors of this book examine the importance of MTHFR in health and disease, including the folate requirements in healthy young women and its potential health implications and the role folate deficiency and MTHFR polymorphisms may play in the complex mechanism of global DNA hypomethylation. Other chapters explore and describe literature data on the involvement of MTHFR gene in HNC development and treatment outcomes and the role of MTHFR and other enzymes in the circulation of methyl in certain neurodegenerative diseases.

(Imprint: Nova Biomedical)

Preface

Chapter 1
MTHFR and Other Enzymes Associated with the Circulation of Methyl in Neurodegenerative Diseases
(Jolanta Dorszewska, Anna Oczkowska, Michał Prendecki, Margarita Lianeri and Wojciech Kozubski, Laboratory of Neurobiology, Department of Neurology, Chair and Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland)
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Chapter 2
Methylenetetrahydrofolate Reductase (MTHFR) in Head and Neck Cancer Development and Treatment
(Ana Lívia Silva Galbiatti, Érika Cristina Pavarino, Eny Maria Goloni-Bertollo, Genetics and Molecular Biology Research Unit (UPGEM), São José do Rio Preto Medical School (FAMERP), São Paulo, Brazil)

Chapter 3
The Role of Folate and of MTHFR C677T Polymorphism in Healthy Young Women
(Antonella Agodi, Martina Barchitta, Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, Italy)

Chapter 4
The Link Between MTHFR C677T Polymorphism, Folate Metabolism and Global DNA Methylation: A Literature Review
(Antonella Agodi, Annalisa Quattrocchi, Andrea Maugeri, Martina Barchitta, Department of Medical and Surgical Sciences and Advanced Technologies “GF Ingrassia”, University of Catania, Catania, Italy)

Index

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