Methionine: Biosynthesis, Chemical Structure and Toxicity


Alexander Snegursky (Editor)
Institute of Electron Physics, Ukrainian National Academy of Sciences, Uzhgorod, Ukraine

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions, Microbiology Research Advances
BISAC: SCI007000

This book is dedicated to a very specific and interesting molecule/substance, Methionine. Methionine belongs to the á-amino acid group and as one of the essential amino acids. Methionine is classified as nonpolar and one of two sulfur-containing proteinogenic amino acids. This substance is an intermediate in the biosynthesis of phospholipids, (i.e. carnitine, cysteine, lecithin, phosphatidylcholine, taurine and others). It is also being utilized by plants in synthesizing ethylene. Methionine is one of only two amino acids encoded by a single codon (AUG) in the standard genetic code. Therefore, it is incorporated into the N-terminal position of all proteins in eukaryotes and archaea during translation, although it is usually removed by post-translational modification. This book deals with the analysis of the most up-to-date data on Methionine properties related to its biosynthesis, electronic structure and toxicity issues. This book would be useful for students, post-graduates and scientists working in the field of studying amino acids, as one of the most prominent members of the family of molecules of biological relevance, tracing their basic properties and analyzing their practical applications in the field of pharmaceutics, medicine and molecular physics. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1. Methionine: A Key Regulatory Compound in Bacteria
(Dvora Biran and Eliora Z. Ron, Molecular Microbiology and Biotechnology Tel Aviv University, Tel Aviv, Israel, and others)

Chapter 2. Methionine and Methylation Balance: Pathways for the Production and Removal of Homocysteine
(Rafael Deminice; Flávia Troncon Rosa and Alceu Afonso Jordao, Department of Physical Education, Faculty of Physical Education and Sport – State University of Londrina, Paraná, Brazil, and others)

Chapter 3. Selected Fast and Slow Methionine Sulfoximine-Inbred Mice: MSO-Dependent Seizures, Behavior, Brain Glycoprofiles, Neurotransmitters and Glycogen
(Arnaud Boissonnet, Tobias Hévor, Richard Daniellou, Ludovic Landemarre and Jean-François Cloix, Institut de Chimie Organique et Analytique, UMR CNRS 7311, Université d’Orléans, France, and others)
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Chapter 4. Methionine Metabolism in Plants: Current Understanding of the Factors Regulating its Metabolism
(Rachel Amir and Yael Hacahm, Laboratory of Plant Science, MIGAL, Galilee Technology Center, Kiryat Shmona, Israel, and others)

Chapter 5. Methionine: Electronic Structure
(Oksana Plekan, Vitaliy Feyer, Robert Richter, Marcello Coreno, Monica de Simone, Kevin C. Prince and Vincenzo Carravetta, Sincrotrone Trieste S.C.p.A., Area Science Park, Strada Statale Trieste, Italy, and others)

Chapter 6. Photoluminescence of Methionine under Laser Excitation
(M.I. Myhovich, Yu.O. Shpenik and V.A. Kelman, Institute of Electron Physics of National Academy of Sciences of Ukraine, Uzhgorod, Ukraine)

Chapter 7. Methionine Molecule Electron-Impact-Induced Fragmentation: Mechanisms and Chemical Structure
(A.V. Snegursky, J. Tamuliene, V.S. Vukstich and L.G. Romanova, Institute of Electron Physics, Ukrainian National Academy of Sciences, Uzhgorod, Ukraine, and others)

Chapter 8. Protective Roles of Transsulfuration against Methionine Toxicity
(Shotaro Kamata and Isao Ishii, Department of Biochemistry, Keio University Graduate School of Pharmaceutical Sciences, Tokyo, Japan)

Chapter 9. Methionine, Homocysteine and Cysteine, and Antiepileptic Drugs in Epilepsy
(Jolanta Dorszewska and Wojciech Kozubski, Laboratory of Neurobiology, Department of Neurology, Poznan University of Medical Sciences, Poznan, Poland)
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