Metabotropic Glutamate Receptors: Molecular Mechanisms, Role in Neurological Disorders and Pharmacological Effects


M. Foster Olive (Editor)
Behavioral Neuroscience Area, Department of Psychology, Arizona State University, Arizona, USA

Series: Neurology – Laboratory and Clinical Research Developments
BISAC: SCI089000

As the most abundant excitatory neurotransmitter in the brain, glutamate plays an important role in numerous aspects of normal and pathological brain function. This book provides an overview of the role of metabotropic glutamate receptors (mGluRs) in basic brain functioning, such as autonomic regulation, synaptic plasticity, and learning and memory. Also provided are up-to-date summaries of recent progress towards identifying how mGluRs both mediate and represent novel pharmacotherapeutic targets for the treatment of various neurological and neuropsychiatric disorders, such as depression, anxiety, schizophrenia, amyloidogenic disorders and substance abuse. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Brainstem Metabotropic Glutamate Receptors and Regulation of Autonomic Responses (pp. 1-22)
A. Díaz-Casares, M. V. López-González and M. S. Dawid-Milner (Universidad de Málaga, Málaga, Spain)

Chapter 2 – Activation of Group I Metabotropic Glutamate Receptors Negatively Regulates Synaptic Plasticity and Network Activity in the Central Nervous System via Inositol 1,4,5-Trisphosphate Receptor Signaling (pp. 23-36)
Jun-Ichi Goto, Satoshi Fujii and Katsuhiko Mikoshiba (Department of Physiology, School of Medicine, Yamagata University, Japan and others)

Chapter 3 – Group I mGluR Receptors as Mediators of Learning and Memory (pp. 37-48)
Lucas R. Watterson and M. Foster Olive (Department of Psychology, Arizona State University, Tempe, Arizona, US)

Chapter 4 – Group I Metabotropic Glutamate Receptors: A Potential Therapeutic Target for Amyloidogenic Disorders (pp. 49-72)
Cara J. Westmark (University of Wisconsin Madison, Wisconsin, US)

Chapter 5 – Metabotropic Glutamate Receptors in the Pathophysiology and Treatment of Schizophrenia and Major Depression (pp. 173-106)
Kelly A. Newell, Natalie Matosin and Jeremy S. Lum (Faculty of Science, Medicine and Health, and Illawarra Health and Medical Research Institute, University of Wollongong, NSW, Australia and others)

Chapter 6 – Metabotropic Glutamate Receptor Subtype 1 (mGluR1) as a Therapeutic Target for Schizophrenia (pp. 107-134)
Gentaroh Suzuki, Hiroshi Kawamoto and Hisashi Ohta (Central Pharmaceutical Research Institute, Japan Tobacco Inc., Takatsuki, Japan and others)

Chapter 7 – Group I and Group II Metabotropic Glutamate Receptors: Role in Pathophysiology and Treatment of Major Depressive Disorder (pp. 135-150)
Elizabeth N. Holly, Amber L. LaCrosse and Todd M. Hillhouse (Tufts University, Medford, Massachusetts, US and others)

Chapter 8 – Involvement of mGluR5 and mGluR2/3 in Drug and Alcohol Dependence (pp. 151-176)
Alessandra Matzeu, Eva Rebecca Zamora-Martinez and Rémi Martin-Fardon (The Scripps Research Institute, La Jolla, California, US)

Chapter 9 – Therapeutic Potential of mGluR Agents on Substance Abuse and Mood Disorders: Role of Stress Reactivity during Abstinence and Withdrawal (pp. 177-226)
Peter R. Kufahl and Sara B. Taylor (Department of Psychology, Arizona State University, Arizona, US)


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