Mesenchymal Stromal Cells (MSCs): Biology, Mechanisms of Action and Clinical Uses

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Randy Morrison (Editor)

Series: Stem Cells – Laboratory and Clinical Research
BISAC: SCI017000

Mesenchymal stromal cells (MSCs) are considered an important tool in tissue engineering due to their multilineage potential in vitro as in vivo beyond their capacity to produce bioactive molecules involved in tissue regeneration. MSCs are essential elements of the microenvironment because they are the precursors of all stromal cells. MSCs influence HPC functions, such as proliferation, apoptosis, and clonogenic growth, directly via cell-cell contacts or indirectly via the secretion of soluble factors. This book reviews the biology, mechanisms of action and clinical uses of MSCs. Chapter One analyzes the modulation of adhesion molecules on MSCs to help in understanding their possible contribution to cancer initiation and progression. Chapter Two studies adipose derived MSCs in cancer therapy. Chapter Three discusses the improvement of clinical uses of MSCs by 3D scaffold-free constructs. Chapter Four reviews the application of MSCs in veterinary medicine. (Imprint: Nova Biomedical)

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Preface

Chapter 1. Optimization of Adhesion Molecule Evaluation on in Vitro-Amplified Bone Marrow-Derived Mesenchymal Stromal Cells from Healthy Donors
Carmen Mariana Aanei, Emmanuelle Tavernier, Denis Guyotat, and Lydia Campos Catafal (Laboratoire d’Hématologie, CHU de Saint-Etienne, Saint-Etienne, Cedex, France, and others)

Chapter 2. The Double Edged Sword of Adipose Derived Mesenchymal Stem/Stromal Cells in Cancer Therapy
Joseph J. Shearer and Marxa L. Figueiredo (Department of Basic Medical Sciences, Purdue University College of Veterinary Medicine, West Lafayette, USA)

Chapter 3. Improving Clinical uses of Mesenchymal Stromal Cells by 3D Scaffold-Free Constructs
Karina Ribeiro Silva, Gabriela Soares Kronemberger, Isis Côrtes, Letícia Emiliano Charelli, Mayra Souza Azevedo, Renata Akemi Morais Matsui, and Leandra Santos Baptista (Biotechnology Post-Graduation Program, National Institute of Metrology, Quality and Technology – INMETRO, Duque de Caxias, RJ, Brazil, and others)

Chapter 4. Application of Mesenchymal Stromal Cells in Veterinary Medicine
Sabrina Renzi, Silvia Dotti and Maura Ferrari (Cell Culture Laboratory and Cellular Immunology, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia Romagna, Brescia, Italy)

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