Melanoma: Molecular Biology, Risk Factors and Treatment Options


Alexander C. Jones (Editor)

Series: Cancer Etiology, Diagnosis and Treatments, Dermatology – Laboratory and Clinical Research
BISAC: MED062000

Melanoma accounts for only 4% of all skin cancer cases but most of skin cancer-related death. The rising incidence of melanoma makes this tumor an important public health problem. In this book, the authors present current research in the study of the molecular biology, risk factors and treatment options for melanoma. Topics include the role of P13K/AKT and Wnt/β-Catenin pathways in melanoma’s progression to metastatic disease; cutaneous melanoma; molecular determinants of melanoma vasculogenic mimicry; new aspects of the molecular biology of melanoma metastasis; the surgical extent of regional lymph node dissection for cutaneous melanoma and its novel techniques and modifications; the epidemiology of melanoma in young individuals; cardiac involvement in malignant melanoma; poor Karnofsky performance status and high serum lactate dehydrogenase level identifies patients with brain metastases from malignant melanoma who do not benefit from palliative whole brain radiotherapy; interferon-beta therapy; and boron neutron capture therapy. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Melanoma Progression to Metastatic Disease: The Role of the PI3K/AKT and Wnt/β-Catenin Pathways
(Jaskiran Sidhu, Geetha Venkateswaran, Sujata Persad, University of Alberta, Department of Pediatrics, Canada)

Cutaneous Melanoma: Molecular Biology, Risk Factors and Treatment Options
(Mariana Aris, Ivana Jaqueline Tapia, Jose Mordoh, Maria Marcela Barrio, Centro de Investigaciones Oncologicas, Fundacion Cancer FUCA, Buenos Aires, Argentina, and others)

Molecular Determinants of Melanoma Vasculogenic Mimicry
(Amalia Vartanian, Anatoly Baryshnikov, N.N. Blokhin Russian Cancer Research Center, Russian Academy of Sciences, Moscow, Russian Federation)

New Aspects of the Molecular Biology of Melanoma Metastasis
(Frédérique Deshayes, Stéphanie Ghislin, Morphogenèse, Homéostasie et Pathologies, Institut Jacques Monod CNRS-Université Paris Diderot Bât.Buffon, Paris Cedex, France, and others)

The Surgical Extent of Regional Lymph Node Dissection for Cutaneous Melanoma and its Novel Techniques and Modifications
(Yasuhiro Nakamura, Yukiko Teramoto, Akifumi Yamamoto, Department of Skin Oncology/Dermatology, Comprehensive Cancer Center, International Medical Center, Saitama Medical University, Saitama, Japan)

Cutaneous Melanoma: Molecular Mechanisms and Current Therapeutic Approaches
(Nathan L. Avaritt, Mahmoud Fade, Matthew Reynolds, Deepanwita Sengupta, Issam Makhoul, Sara Shalin, Alan J. Tackett, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA)

Epidemiology of Melanoma in Young Individuals: A Systematic Review
(Adeel S. Zubair, Jerry D. Brewer, Division of Dermatologic Surgery, Department of Dermatology, Mayo Clinic/Mayo Clinic College of Medicine, Rochester, MN, USA)

Cardiac Involvement in Malignant Melanoma
(Antonella Fontana, Department of Cardiology, St. Gerardo Hospital and University of Milan-Bicocca, Monza, Italy)

Poor Karnofsky Performance Status and High Serum Lactate Dehydrogenase Level (KPS/LDH Index) Identifies Patients with Brain Metastases from Malignant Melanoma who do not Benefit from Palliative Whole Brain Radiotherapy
(Richard Partl, Erika Richtig, Alexander Avian, Andrea Berghold, Karin S. Kapp, Department of Therapeutic Radiology and Oncology, Medical University of Graz, Auenbruggerplatz, Graz, Austria, and others)

Short Communication:
Interferon-Beta Therapy for Melanoma: A Review of the Literature
(Yuta Kurashige, Tetsuo Nagatani, Department of Dermatology, Hachioji Medical Center of Tokyo Medical University, Tokyo, Japan)

Boron Neutron Capture Therapy for Melanoma Treatment
(Fernanda Faião Flores, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil)


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