Matrix Metalloproteinases (MMPs): Classification, Molecular Mechanisms and Roles in Diseases


Jeremiah Sullivan (Editor)

Series: Biochemistry Research Trends
BISAC: MED008000

Matrix metalloproteases (MMPs) include a group of enzymes important in the degradation of components of the extracellular matrix (ECM) and are thought to be universally related to pathology. This book examines the relationship between matrix metalloproteinases (MMPs) and oral pathologies, including oral squamous cell carcinoma and separately, atherosclerosis.

The molecular mechanisms regarding MMPs activation and the use of MMP inhibitors as an effective treatment in animal models of hypertension are reviewed. The status of MMPs and their regulators with infectious diseases of bacterial and protozoan origin that invade host through mucosal surfaces are explored. Finally, a clinical point of view is provided for the association between MMPs and bowel diseases.
(Imprint: Nova)


Table of Contents

Table of Contents


Chapter 1
Up-Regulation of Matrix Metalloproteases in Cancer and Atherosclerosis, Role of Inflammation
(T. A. Korolenko, T. P. Johnston, Y. A. Kisarova, and M. S. Cherkanova, Institute of Physiology and Fundamental Medicine, Novosibirsk, Russia, and others)

Chapter 2
Roles of Matrix Metalloproteinases in Periodontal Diseases and Dental Caries
(Eman Allam, Sabrina Feitosa, Jadesada Palasuk, Marco C. Bottino and L. Jack Windsor, Indiana University School of Dentistry, Indianapolis, IN, USA)
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Chapter 3
Metalloproteinases: Prognostic and Predictive Biomarkers of Radiation Response
(Ríos, F Artacho, A Olivares, I Calvente, M Salinas and MI Núñez, Department of Radiology and Physical Medicine, University of Granada, Granada, Spain, and others)

Chapter 4
Matrix Metalloproteinases: Pathophysiological Mechanisms in Hypertension
(Carla Speroni Ceron, Marcelo Rizzatti Luizon and Jose E Tanus-Santos, Faculty of Pharmaceutical Sciences, Federal University of Alfenas (UNIFAL), Rua Gabriel Monteiro da Silva, Alfenas, Minas Gerais, Brazil, and others)

Chapter 5
Prognostic Value of Matrix Metalloproteinases in Oral Squamous Cell Carcinoma
(Georgi Mishev, Valentin Djonov, Institute of Anatomy, University of Bern, Baltzerstrasse, Bern, Switzerland)

Chapter 6
Mucosal Barriers, MMPs and Infectious Diseases: Conflict or Resolution?
(Andrea Cristina Vetö Arnholdt, Laboratório de Biologia do Reconhecer, Centro de Biociências e Biotecnologia, Universidade Estadual do Norte Fluminense, Brazil)

Chapter 7
Matrix Metalloproteinases and Bowel Diseases – A Clinical Point of View
(Stelian Stefanita Mogoanta, Laurentiu Mogoanta, Department of Surgery, University Of Medicine and Pharmacy of Craiova;Postdoc Researcher, University of Medicine and Pharmacy “Carol Davila”, Bucharest, Romania, and others)



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