Mast Cells: Phenotypic Features, Biological Functions and Role in Immunity


David B. Murray (Editor)
Department of Pharmacology, University of Mississippi School of Pharmacy, MS, USA

Series: Cell Biology Research Progress
BISAC: SCI017000

Resident mast cells are uniquely positioned in multiple organ systems at either the tissue and/or external environment or located near nerve endings and/or blood vessels. These locations allow the mast cell to serve as a sentinel and thus play a critical role in not only inflammatory situations to promote recruitment and infiltration of other immune cells, but also homeostatic maintenance.

Although mast cells have several conserved characteristics, the authors provide evidence that the micro-environment influenced differences in the phenotype of tissue-specific mast cells, control the various responses to injury, inflammation and remodeling. This book brings together the work from experts across multiple tissue/organ systems and inflammatory causes (viral, bacterial, and autoimmune) to present the most up to date knowledge regarding the role of mast cells in these regulatory and disease events. (Imprint: Nova Biomedical )


Table of Contents

Table of Contents

Chapter 1- Role of Mast Cells in Health and Disease
(Zoulfia Allakhverdi, Laboratory on Allergy Research, CHUM Research Center, Notre-Dame Hospital, Montreal, Quebec, Canada)

Chapter 2- Spatial Patterns in Mast Cell Activation
(Kathrin Spendier and James L. Thomas, University of Mexico, Albuquerque, NM, USA)

Chapter 3- Mast Cells within the Microenvironment: Cellular and Matrix Cross-talk in Physiopathological Conditions
(Barbara Frossi, Elena Betto and Giorgia Giri, Department of Medical and Biological Science, University of Udine, Udine, Italy)

Chapter 4- Mast Cell in Immune Function and Leukocyte Recruitment
(Albert F. De Felice, Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, Food and Drug Administration, Silver Spring, MD, USA)

Chapter 5- The Function of Mast Cells in Innate Immunity: Interaction of Mast Cells with Gram-Negative Bacteria
(Sibylle A. Brenner and Axel Lorentz, Institute of Nutritional Medicine University of Hohenheim Stuttgart, Germany)

Chapter 6- Presentation, Diagnosis, and Management of Mast Cell Activation Syndrome
(Lawrence B. Afrin, Division of Hematology/Oncology, Medical University of South Carolina, Charleston, SC, USA)
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Chapter 7- Multiple Roles of Mast Cells in Heterotropic Ossification
(Lixin Kan, Department of Neurology, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA)

Chapter 8- The Role of Mast Cells in Neoplasm Angiogenesis and Bacterial and Viral Infections
(Moges Woldemeskel, College of Veterinary Medicine, Department of Pathology, Tifton Veterinary Diagnostic and Investigational Laboratory, The University of Georgia, Tifton, GA, USA)

Chapter 9- Mast Cells and Their Evolving Role in the Human Testis
(Artur Mayerhofer, Christoph Schell, Katrin Spinnler, Marion Adam and Harald Welter, Anatomy III-Cell Biology, Ludwig-Maximilians-Universität (LMU) Munich, Munich, Germany)

Chapter 10- Mast Cells in Inflammatory Bowel Disease: Potential Therapeutic Targets for Intestinal Inflammation and Fibrosis
(Kenji Suzuki, Masaki Nagata, Tomoyuki Kawase, Yutaka Honda, Yusuke Kawauchi, Junji Yokoyama, Somasundaram Arumugam, Hiroyuki Yoneyama,
Kenichi Watanabe and Hitoshi Asakura, Department of Medicine, Niigata University Medical and Dental Hospital, Niigata, Japan and others)



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