Mast Cells and their Role in Health and Disease



: Immunology and Immune System Disorders
BISAC:MED014000; MED018000

This book presents a review concerning the role of mast cells in health and disease. Mast cells were first described by Paul Erlich in his PhD thesis and are considered the remaining cells of an ancient immune system. Indeed, they are placed in common portals of infection, like the urinary and respiratory tracts.

The first chapter addresses the role of mast cells in cancer development and progression. Chapters II and III address the role of mast cells in periodontal disease and oral lichen planus, respectively. The role of brain mast cells in neuroinflammation and cognition was described in Chapter IV.

Together, these chapters provide the readers an overview of the role of mast cells in different conditions.

Since the information presented in this book was obtained from years of works of expertise in the field, we hope that it will be useful for those researchers aiming to better understand the role of mast cells in different conditions.

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Table of Contents



Chapter 1. Role of Mast Cells in Tumor Growth
(Shikha Saxena, Akshay Bhargava, Priyanka Singh and Akhilesh Chandra – Department of Oral Pathology & Microbiology, RUHS College of Dental Sciences, Jaipur, Rajasthan, India, et al.)

Chapter 2. Role of Mast Cells in Periodontal Disease
(Neetha Bhargava, Akshay Bhargava, Pradeep Chaudhary and Rohit Sharma – Department of Periodontics, NIMS Dental College, NIMS University, Jaipur, Rajasthan, India et al.)

Chapter 3. Role of Mast Cells in Oral Lichen Plants
(Akshay Bhargava, Neetha Bhargava, Shikha Saxena, Krishna Sireesha Sundaragiri, Bharat Sankhla and Vatchala Rani – Associate professor, Department of Oral Pathology and Microbiology, RUHS College of Dental Sciences, Jaipur, India, et al.)

Chapter 4. Brain Mast Cells, Neuroinflammation and Cognition
(Theoharis C. Theoharides – Laboratory of Molecular Immunopharmacology and Drug Discovery, Department of Immunology, Tufts University School of Medicine, Boston, MA, USA, et al.)

About the Editors

List of Contributors


Editor’s ORCID iD

Ana I. Faustino –
Paula A. Oliveira –

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