Major Depressive Disorder: Risk Factors, Characteristics and Treatment Options


Yong-Ku Kim (Editor)
Department of Psychiatry, Korea University Ansan Hospital, Gojan-Dong, Danwon-Gu, Kyunggido, Republic of Korea

Series: Psychiatry – Theory, Applications and Treatments
BISAC: MED105000

This book focuses on risk factors, clinical and biological characteristics, and treatment options for depression. The aim of this book is to provide readers with an up-to-date understanding of the clinical and neurobiological underpinnings of depression as well as promising treatment for depression. The book is divided into five sections, the first of which examines the clinical heterogeneity of depression. Clinical symptoms, risk factors and treatment options of depression during neurodevelopment and neurodegeneration periods differ from those of depression in adults. Section II highlights bio-psychosocial factors in depression. Major depression cannot be understood without considering the psychosocial environment. Interaction between genetic susceptibility and the psychosocial context affect the occurrence of major depression. Section III focuses on biomarkers of depression. It covers from the overview of biomarkers, focusing on diagnosis, subtyping of depression and treatment response prediction to neuroimaging, genetics, and serum markers in depression. Section IV covers neurobiology and management for treatment-resistant depression. It discusses the etiological issues of treatment-resistant depression including genetic susceptibility, structural and functional MRI markers, neurogenesis, neuroinflammation and neuromodulation treatment for treatment-resistant depression. Section V highlights new perspectives of depression. Neurotrophic hypothesis-driven BDNF-TrkB signaling pathways and downstream of neurotransmitters have attracted attention to new pharmacologic targets. Homeostatic regulation of sleep, its dysregulation in mood disorders, and updated theories between inflammations and depression are discussed. The book will provide a better understanding of clinical and biological features and the management of depression, and will also function as a step onto the path toward the ultimate goal of predicting, preventing and treating depression. (Imprint: Nova)

Table of Contents

Table of Contents


Section I. Clinical Heterogeneity of Major Depressive Disorder

Chapter 1. Risk Factors, Clinical Characteristics, and Treatment Options of Depressive Disorders in Children and Adolescents
Se-hoon Shim (Departement of Psychiatry, School of Medicine Soonchunhyang University, Cheonan, South Korea)

Chapter 2. Risk Factors and Clinical Characteristics of Old-Age Depression
Kang Joon Lee (Department of Psychiatry, College of Medicine, Inje University, Ilsan Paik Hospital, Republic of Korea)

Chapter 3. Major Depressive Disorder and Vascular Diseases: The Unbearable Lightness of Bidirectionality
Emre Sarandol (Uludag University, Medical Faculty, Department of Clinical Biochemistry, Bursa, Turkey)

Chapter 4. Issues in the Classification of Psychotic Depression
Seon-Cheol Park, MD, PhD and Joonho Choi, MD, PhD (Department of Psychiatry, Inje University Haeundae Paik Hospital, Busan, Republic of Korea, and others)

Section II. Major Depressive Disorder and Bio-Psycho-Social Approach

Chapter 5. Bio-Psycho-Social Risk Factors for Depression
Sang Won Jeon, Meysam Amidfar and Yong-Ku Kim (Department of Psychiatry, College of Medicine, Korea University, Ansan Hospital, Republic of Korea)

Chapter 6. Suicide Risk Factors and Prevention Programs in Major Depressive Disorder
Sunju Kim and Jong-Woo Paik (Department of Psychiatry, College of medicine, Kyung-Hee University, Seoul, Republic of Korea)

Chapter 7. Neurobiology and Treatment Options of Major Depressive Disorder in Suicidal Situations
Ki Won Kim and Hong Jin Jeon (Department of Psychiatry, Depression Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea)

Section III. Biomarkers of Major Depressive Disorder

Chapter 8. Diagnosis and Prognosis of Major Depressive Disorder: From Clinical to Biological Applications
Mike C. Jentsch, Fokko J. Bosker and Robert A. Schoevers (University Centre of Psychiatry, University of Groningen, University Medical Centre of Groningen, The Netherlands)

Chapter 9. Structural Neuroimaging Studies in Major Depressive Disorder: Progress toward a Biomarker for Depression
Kang Soo Lee, MD and Sang-Hyuk Lee, MD (Department of Psychiatry, School of Medicine, CHA University, CHA Bundang Medical Center, Seongnam, Korea)

Chapter 10. Biomarkers of Treatment Response in Depression
Gordana Nedic Erjavec, PhD, Matea Nikolac Perkovic, PhD, Dubravka Svob Strac, PhD, and Nela Pivac, PhD (Rudjer Boskovic Institute, Division for Molecular Medicine, Laboratory for Molecular Neuropsychiatry, Zagreb, Croatia)

Section IV. Neurobiology and management for treatment-resistant depression

Chapter 11. Treatment-Resistant Depression: Neurobiological Etiology and Pharmacological Treatment Strategies
Kyoung-Sae Na, kwang-Yeon Choi and Yong-Ku Kim (Department of Psychiatry, Gachon University Gil Medical Center, Republic of Korea, and others)

Chapter 12. Neuromodulation for Treatment-Refractory Depression
Ralph J. Koek, MD, Arkady Korotinsky, MD, Nicholas Athanasiou, MD, MBA, and Janine Roach, MD (Mood Disorders Clinic, Sepulveda Ambulatory Care Center, VA Greater Los Angeles Healthcare System and UCLA/San Fernando Valley Psychiatry Training Program, Los Angeles, US, and others)

Section V. New Perspectives on Major Depressive Disorder

Chapter 13. BDNF Receptor TrkB as a Target of Antidepressants
Tomi Rantamäki (Laboratory of Neurotherapeutics, Division of Physiology & Neuroscience, Department of Biosciences, Faculty of Biological & Environmental Sciences, University of Helsinki, Finland)

Chapter 14. Updated Theories between Inflammations and Major Depression
Hee Jung Yoon and Se-hoon Shim (The Korean Society of Infectious Diseases, Seoul, Republic of Korea, and others)


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