Magnetic Resonance Imaging in Stem Cell Applications

Xiaoming Yang (Editor)
Department of Radiology, University of Washington School of Medicine, Seattle, WA, USA

Series: Stem Cells – Laboratory and Clinical Research
BISAC: SCI093000

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Stem cell-based regenerative therapy has become a frontier in modern medicine. For the success of both basic research and clinical application of stem cell technology, it is essential to have noninvasive methods to monitor the delivery of transplanted stem cells, track migration/homing of stem cells to the targets, and assess survival and function of the transplanted stem cells at the targets. Magnetic resonance imaging (MRI) represents a promising technology fitting in this necessity. So far, scientists from various disciplines around the world have done outstanding works in developing different MR techniques for in vivo imaging of stem cells, so-called cellular MRI.

The aim of this book is to facilitate such translation of advanced cellular MRI techniques from laboratory benches to pre-clinical animal studies, and, ultimately, to clinical practice. The authors are from several continents around the world, with their expertise in the fields of stem cell science, biomedical engineering, medicine, pathology, medical imaging, and interventional radiology. We hope this book will provoke common interests, brainstorming and cooperation among professionals in both stem cell science and medical imaging, and bring regenerative medicine one step closer to benefiting the patients. (Imprint: Nova Biomedical)

Foreword

Preface

Contributing Authors

SECTION I. OVERVIEW

Chapter 1 - Stem Cells: The Basic Concept (pp. 3-18)
Hongxiu Ji and Kristiina O. Yang (University of Washington School of Medicine, Seattle, and others)

Chapter 2 - Magnetic Resonance Imaging of Stem Cells: The Principles (pp. 19-44)
Rohan Dharmakumar, Avinash Kali and Debiao Li (Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA)

Chapter 3 - Direct Magnetic Labeling of Stem Cells (pp. 45-56)
Bensheng Qiu, Thomas Matula, Norman Beauchamp Jr. and Xiaoming Yang (Image-Guided Bio-Molecular Intervention Research, Department of Radiology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, USA)

Chapter 4 - Indirect Magnetic Labeling of Stem Cells (pp. 57-80)
Anna V. Naumova and Charles E. Murry (Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA)

Chapter 5 - Strategies for Delivery of Stem Cells (pp. 81-86)
Sandeep Vaidya and Manjiri Dighe (Division of Interventional Radiology, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA)

SECTION II. APPLICATIONS

Chapter 6 - Magnetic Resonance Imaging of Stem Cell Application in Neurology (pp. 89-104)
Antje Arnold, Miroslaw Janowski and Piotr Walczak (The Russell H. Morgan Department of Radiology and Radiological Science; Division of MR Research, Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA)

Chapter 7 - Magnetic Resonance Imaging of Stem Cell Application in Liver (pp. 105-116)
Weitao Ye, Changhong Liang and Bin Zhou (Department of Radiology, Guangdong General Hospital, Guangzhou, Guangdong, China)

Chapter 8 - Magnetic Resonance Imaging of Stem Cell Application in Oncology (pp. 117-136)
Mariangela Sottili, Chiara Gerini and Monica Mangoni (Radiotherapy Unit, Department of Experimental and Clinical Biomedical Sciences, University of Florence, Firenze, Italy)

Chapter 9 - Magnetic Resonance Imaging of Stem Cell Application in Heart (pp. 137-158)
Morteza Mahmoudi and Phillip C. Yang (Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA)

Chapter 10 - Creation of Animal Models for Magnetic Resonance Imaging of Stem cell Application in Vasculatures (pp. 159-176)
Feng Zhang, Yaoping Shi and Xiaoming Yang (Image-Guided Bio-Molecular Intervention Research, Department of Radiology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, USA)

Chapter 11 - Magnetic Resonance Imaging of Stem Cell Application in Vasculatures (pp. 177-186)
Yanfeng Meng and Xiaoming Yang (Image-Guided Bio-Molecular Intervention Research, Department of Radiology, Institute for Stem Cell and Regenerative Medicine, University of Washington School of Medicine, Seattle, Washington, USA)

Chapter 12 - Magnetic Resonance Imaging in Clinical Application of Stem Cells: Current Status (pp. 187-198)
Wayne L. Monsky (Department of Radiology, University of Washington Medical Center, Seattle, Washington, USA)

Index

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