Lung Cancer: A Comprehensive Overview

Kathy Gately, PhD (Editor)
Thoracic Oncology Research Group, Dept. of Clinical Medicine, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James Hospital, Dublin, Ireland

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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Lung cancer is the leading cause of cancer related death in both men and women worldwide. The impact of this devastating disease on society is phenomenal with patient outcomes only marginally improving over the past four decades and the cost of treatment constantly rising. However, recent technological advances in how we diagnose cancer and the advent of targeted therapies allows a more personalised approach to patient treatment paving the way for real improvements in lung cancer management.

This book provides a comprehensive overview of lung cancer in the 21st century. It describes in detail the histopathology of the disease and how tumours are staged. It outlines the epidemiology of the disease and the role of chronic obstructive pulmonary disease (COPD), cigarette smoke, radon and occupational exposures in the incidence of lung cancer. An in depth overview of the current recommended treatment options for lung cancer patients depending on stage is presented, highlighting the relevant clinical trials that have changed clinical practice. An insight into many of the molecular mechanisms involved in resistance to therapy and recent developments in targeted therapies are reviewed extensively. Finally, the molecular biology of lung carcinogenesis, progression and the link between inflammation and lung cancer are examined. (Imprint: Nova Biomedical )

Preface

Chapter 1. The Pathology of Lung Cancer
(Niamh Leonard, St. James’s Hospital, Dublin, Ireland)

Chapter 2. Introduction to Lung Cancer, its Epidemiology and Diagnosis
(Stephen A. Deppen and Eric L. Grogan, Department of Thoracic Surgery, Vanderbilt University Medical Center, TN, USA and others)

Chapter 3. The Effect of Smoking Habit Intensity, Occupation, Diet and Lung Cancer Risk in Males
(Agustina Bertola Compagnucci, María S. Dagatti and Stella M. Pezzotto, Instituto de Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Argentina)

Chapter 4. Lung Cancer: Treatment in Early Stage
(Miriam Méndez, Ana Custodio and Mariano Provencio, Medical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain and others)

Chapter 5. Lung Cancer: Treatment in Advanced Stages
(Miriam Méndez, Ana Custodio and Mariano Provencio, Medical Oncology Department, Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain and others)

Chapter 6. Management of Stage III N2 NSCLC
(Mark J. Krasna, Meridian Cancer Care, Neptune, NJ, USA)

Chapter 7. Targeted Therapies in Non-Small Cell Lung Cancer
(Susan Heavey, Ken O’Byrne and Kathy Gately, Department of Clinical Medicine, Trinity College Dublin, St. James’s Hospital, Dublin, Ireland)

Chapter 8. Molecular Mechanisms of Cisplatin Resistance in Lung Cancer
(Martin P. Barr and Ken O’Byrne, Thoracic Oncology Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St. James’s Hospital and Trinity College Dublin, Ireland)

Chapter 9. Inflammation in Lung Carcinogenesis
(Anne-Marie Baird, Steven G. Gray and Ken O’Byrne, Department of Clinical Medicine, Trinity College Dublin, St. James’s Hospital, Dublin, Ireland)

Chapter 10. The Link between Chronic Obstructive Pulmonary Disease and Lung Cancer: Novel Molecular Insights
(Nikoletta Rovina and Fotis Vlastos, Pulmonary and Critical Care Medicine, Sotiria Hospital, University of Athens, Athens, Greece)

Chapter 11. Diagnosis, Treatment and Follow-up of Neoplastic Pericardial Disease in Lung Cancer
(Chiara Lestuzzi, Massimiliano Berretta, Alessandra Bearz and Witold Tomkowski, Cardiology, CRO, National Cancer Institute, Aviano (PN), Italy and others)

Chapter 12. The Role of Claudin Proteins in Lung Tumorigenesis
(Zhe Lu, Qun Lu, Lei Ding and Yan-Hua Chen, Department of Anatomy and Cell Biology, Leo W. Jenkins Cancer Center, Brody School of Medicine, East Carolina University, Greenville, NC, USA and others)

Chapter 13. The Role of the Arachidonic Acid Signalling Pathway in NSCLC Development and Progression: Novel Targets for Therapeutic Intervention
(Mary-Clare Cathcart, Ken O’Byrne and Graham P. Pidgeon, Department of Surgery, Trinity College Dublin, St. James’s Hospital, Dublin, Ireland)

Index

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