Liposomes: Historical, Clinical and Molecular Perspectives


Benjamin R. Pearson (Editor)

Series: Cell Biology Research Progress
BISAC: SCI017000

Chapter One is addressed to a comprehensive revision of the bibliography regarding the emergence of liposomes and the first steps in their design, the type of systems (components and structures), their classification and properties. Chapter Two discusses the possibility of creating living ‘synthetic’ cells. Chapter Three provides an overview of the development and application of liposomes in biomedical sciences, with special emphasis on recent advances in the investigation of multifunctional liposomes that target cells and cellular organelles with a single delivery system. In Chapter Four, the authors review the mechanisms of drug transport through the BBB using liposomes, and the design strategies for optimum liposomal properties. In Chapter Five, the development rationales and structural types of pH-sensitive liposomes is discussed Chapter Six presents the characteristic, classification and preparation methods of liposomes. To develop liposomal drug delivery system, functional liposomes including antibody-conjugating liposomes known as immunoliposomes and stimuli-triggered liposomes such as pH- and thermo-sensitive liposomes have been investigated in Chapter Seven. Chapter Eight covers the use of thermosensitive liposomes for drug delivery and cancer therapy, because the side-effects of anticancer drugs are restrained and drug release can be controlled in combination with local hyperthermia. In Chapter Nine, the authors summarize the potential of OMLs as a novel adjuvant and antigen delivery vehicle for induction of encased antigen-specific strong T cell immunity. Chapter Ten presents the recent advances of liposomes in drug and vaccine delivery and shed light to the application of DSC to thermodynamic characterization of liposomal delivery platforms. Chapter Eleven focuses on various liposomal delivery systems that are currently being explored to overcome the anatomical and physiological obstacles to improve the delivery efficiency of BNCT to brain glioma cells. (Imprint: Nova Biomedical)


Table of Contents

Table of Contents


Chapter 1. Liposomes: From the Pioneers to Epigenetic Therapy
Luciano Benedini, Nancy Andres and Maria Laura Fanani (Institute of Southern Chemistry (INQUISUR-CONICET), Department of Chemistry, Universidad Nacional del Sur, Bahía Blanca, Argentina, and others)

Chapter 2. The Birth of Liposome-Based Synthetic Biology: A Brief Account
Pasquale Stano (DiSTeBA, University of Salento; Lecce, Italy)

Chapter 3. The Development and Application of a Liposomal Delivery System in Biomedical Sciences
Scarlet Xiaoyan Wang, Xuesong Wen and Jindao Wu (Department of Natural Sciences, Middlesex University, London, UK, and others)

Chapter 4. Advancements in Liposomes for Targeted Drug Delivery against Neurodegenerative Diseases
Joy N. Reginald-Opara, Justin Dean, PhD and Zimei Wu, PhD (School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, and others)

Chapter 5. pH-Sensitive Liposomes for Intracellular and Tumour Targeted Drug Delivery
Mimi M. Yang, Manju Kanamala, Mingtan Tang and Zimei Wu, PhD (School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand)

Chapter 6. Liposomes as Drug Delivery Carriers for Cancer Therapy
Qi Sun and Nan Li (School of Pharmaceutical Science and Technology, Tianjin University, Tianjin, PR China)

Chapter 7. Immunoliposomes: Recent Progress of Liposomal Drug Delivery System Coupled with Antibodies
Tsukasa Shigehiro and Masaharu Seno (Department of Medical Bioengineering, Graduate School of Natural Science and Technology, Okayama University, Okayama, Japan)

Chapter 8. Visualization of Magnetic Thermosensitive Liposomes Using Magnetic Particle Imaging and Drug Release Control
Kenya Murase, Kazuki Shimada and Shuki Maruyama (Department of Medical Physics and Engineering, Graduate School of Medicine, Osaka University, Osaka, Japan)

Chapter 9. Oligomannose-Coated Liposomes: An Efficient Platform for Vaccines for Tumor Immunotherapy, Allergies, and Infectious Diseases
Yuko Matsuoka, Yasuhiro Kuroda and Naoya Kojima (Department of Applied Biochemistry, Tokai University, Hiratsuka, Kanagawa, Japan)

Chapter 10. The Thermal Analysis of Liposomal Formulations as an Element to Evaluate their Effectiveness as Drug and Vaccine Delivery Systems
Nikolaos Naziris, Natassa Pippa, Stergios Pispas and Costas Demetzos (Section of Pharmaceutical Technology, Department of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens, Greece, and others)

Chapter 11. Liposome-Based Boron Neutron Capture Therapy for Brain Glioma: Current and Future Perspectives
Weirong Kang, Darren Svirskis, PhD, and Zimei Wu, PhD (School of Pharmacy, The University of Auckland, Auckland, New Zealand)



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