Lipid Rafts: Properties, Controversies and Roles in Signal Transduction


Dan Sillence, PhD (Editor)
De Montfort University, Leics, United Kingdom

Series: Cell Biology Research Progress
BISAC: SCI017000

For many years, the surface of cells was viewed as a homogeneous fluid lipid casing. However, it is now understood that the surface of cells are not homogeneous but instead contains domains selectively enriched in particular lipids and proteins. Although it is still not completely clear how these lipid platforms are formed, their existence provides a basis for the organization of many cell processes. One possibility is that microdomain formation relies on lipid phase separation in the plane of the bilayer – ‘lipid raft’ hypothesis.

Lipid rafts are compelling since they provide spontaneous organization for signal transduction as well as intracellular sorting and targeting. What are the functions of these domains? Do they rely on specific interactions and how do they change in response to cell signaling processes? Do they help in the understanding of cell signaling and immune function and how may they be disrupted in disease processes such as neurodegeneration? (Imprint: Nova Biomedical )


Table of Contents

Table of Contents


Chapter 1. The Role of Glycosphingolipids in Lipid Rafts: Lessons from Knockout Mice
(Koichi Furukawa, Yusuke Ohmi, Yuji Kondo, Yuki Ohkawa, Noboru Hashimoto, Orie Tajima and Keiko Furukawa, Department of Biochemistry II, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan and others)

Chapter 2. Biophysics of Lipid Rafts and their Interplay with Ceramide: Studies in Model Systems and Biological Insights
(Rodrigo F.M. de Almeida, Joaquim T. Marquês and Liana C. Silva, Centro de Química e Bioquímica, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Lisboa, Portugal and others)

Chapter 3. Caveolae as Specialized Lipid Rafts: Diverse Roles in the Regulation of Potassium Channel Signalling
(Dominic Byrne and Caroline Dart, Institute of Integrative Biology, University of Liverpool, United Kingdom)

Chapter 4. The Role of Caveolin-Enriched Microdomains in the Regulation of Cellular Signalling and Energy Homeostasis
(Christopher Lipina, Mitchell H. Whyte, Clare Stretton and Harinder S. Hundal, Division of Cell Signalling & Immunology, College of Life Sciences, University of Dundee, Dundee, United Kingdom)

Chapter 5. Maintaining a Healthy Immune Response by Balancing the Lipid Content of Lipid Raft Microdomains
(Georgia McDonald, Panagiotis S. Kabouridis and Elizabeth C Jury, Centre for Rheumatology Research, Department of Medicine, University College London, Rayne Building, London, United Kingdom)

Chapter 6. Lipid Rafts and Signal Transduction in Mast Cells
(Vivian Marino Mazucato, Adriana Maria Mariano Silveira e Souza, Maria Célia Jamur and Constance Oliver, Department of Cell and Molecular Biology and Pathogenic Bioagents, Faculdade de Medicina de Ribeirão Preto – University of São Paulo, Ribeirão Preto, SP – Brazil)
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Chapter 7. The Role of Lipid Rafts in Neurodegenerative Diseases
(Clive Bate, Department of Pathology and Infectious Diseases, Royal Veterinary College, North Mymms, Herts, United Kingdom)

Chapter 8. Neuronal Lipid Raft Perturbations as Key Elements of Early Neurodegeneration: A Challenge in the Search of New Tools for Early Diagnosis
(Raquel Marin and Mario Diaz, Laboratory of Cellular Neurobiology, Department of Physiology, School of Medicine, La Laguna University, Tenerife, Spain and others)



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