Ligands: Synthesis, Characterization and Role in Biotechnology


Paula Gawryszewska, D.Sc.Eng (Editor)
University of Wrocław, Wrocław, Poland

Piotr Smoleński, D.Sc.Eng (Editor)
Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland

Series: Biochemistry Research Trends
BISAC: SCI007000

To meet the search for new therapeutic compounds this book summarizes the research on biologically active organic molecules (chapters 1, 2 and 3), metal complexes with biological activity (chapter 4), and shows the possibilities for coordination chemistry in the planning of metal complexes with interesting properties for application (chapters 5, 6, 7, 8, and 9). It should be remembered that in the design of a new potentially active metallodrug, beyond the nature of the metal, the choice of appropriate ligands which affect the thermodynamic and kinetic stability, as well as the solubility and lipophilicity of the complexes is of paramount importance.

The information contained in the book concerns: 1) the interactions involving the members of the Nuclear Receptor superfamily and their ligands; 2) the role of chemokine ligands and their receptors in normal and disease processes, and the emerging therapeutic approaches of using chemokine antagonists for appropriately targeted therapy; 3) the inhibition of alkaline phosphatases by calix[4]arenes functionalysed at the macrocyclic upper rim by one or two methylenebisphosphonic acid fragments; 4) the main biological applications, enzyme modelling and antiproliferative and antimicrobial activity of such scorpionate-type complexes, which are classified by ligand and also by transition metal; 5) the silver(I) discrete and polymeric coordination compounds bearing 1,3,5-triaza-7-phosphaadamantane or its derivatives towards engineering functional silver-organic frameworks (MOFs); 6) arylhydrazones of methylene active nitriles and their use as starting materials for the generation of new organic and coordination compounds; 7) amidophosphate ligands as promising sensitizers of lanthanide ions emission; 8) N-acetylsalicylhydrazidate as a versatile ligand for the synthesis of higher nuclearity metal complexes, which are illustrated herein along with their applications; 9) the chemistry and some applications of formazans which can be used for the simultaneous selective determination of several metal cations. All chapters were compiled by renowned scientists, providing both beginners in the field and advanced researchers with comprehensive information on the subject. (Imprint: Nova)




Table of Contents


Chapter 1. Ligand Interactions in Nuclear Receptors
(Ana Carolina Mafud, Jademilson C. dos Santos and Alessandro S. Nascimento, Instituto de Fisica de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil)

Chapter 2. The Role of Chemokine Ligands in Human Health and Disease
(Ning Li, Canhua Jiang, Feng Guo, Tong Su, Xinqun Chen, Lian Zheng and Xinchun Jian, Department of Oral and Maxillofacial Surgery, Xiangya Hospital, Central South University, Changsha, P.R. China)

Chapter 3. Calix[4]arene Methylene Bisphosphonic Acids as Effectors of Biochemical Processes
(S.V. Komisarenko, S.O. Kosterin, E.V. Lugovskoy, S.O. Cherenok, V. Yu. Tanchuk, A.I. Vovk and V.I. Kalchenko, Palladin Institute of Biochemistry, Kyiv, Ukraine and others)

Chapter 4. Synthesis and Biological Applications of Tris(pyrazol-1-yl)-Methane and Borate Metal Complexes
Luísa M. D. R. S. Martins, Elisabete C. B. A. Alegria and Armando J. L. Pombeiro, Chemical Engineering Department, Instituto Superior de Engenharia de Lisboa, R. Conselheiro Emídio Navarro, Lisboa, Portugal and others)

Chapter 5. Coordination Engineering with 1,3,5-Triaza-7-Phosphaadamantane (PTA) towards Biologically Active Silver-Organic Frameworks
(Piotr Smolenski, Faculty of Chemistry, University of Wroclaw, Wroclaw, Poland)

Chapter 6. Arylhydrazones of Methylene Active Nitriles as Promising Ligands and Starting Materials for Organic Synthesis
(Kamran T. Mahmudov, Maximilian N. Kopylovich, Armando J. L. Pombeiro, Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon, Portugal and others)

Chapter 7. Powerful New Ligand Systems: Carbacylamidophosphates (CAPh) and Sulfonylamidophosphates (SAPh)
(V. Amirkhanov, V. Ovchinnikov, V. Trush, P. Gawryszewska and L. B. Jerzykiewicz, Taras Shevchenko National University of Kyiv, 64/13, Volodymyrska Street, City of Kyiv, Ukraine and others)

Chapter 8. Synthezis, Applications and Coordination Chemistry of Formazans
(Yauhen Yu. Karabach and Maximilian N. Kopylovich, Centro de Química Estrutural, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon, Portugal)

Chapter 9 N-Acetylsalicylhydrazidate: A Versatile Ligand for the Synthesis of Higher Nuclearity Complexes
(Manas Sutradhar and Armando J. L. Pombeiro, Centro de Química Estrutural, Complexo I, Instituto Superior Técnico, Universidade de Lisboa, Lisboa, Portugal)



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