Leydig Cells: Structure, Functions and Clinical Aspects

Bruno Solomon (Editor)

Series: Cell Biology Research Progress
BISAC: SCI017000

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Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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The main function of the Leydig cells is to synthesize testosterone, but growing evidence supports the idea that Leydig cells are important in regulating the testicular immune environment. As such, Leydig Cells: Structure, Functions and Clinical Aspects discusses Leydig cells serving as immunological sentinels in the testis.
Next, the authors explore the commercially available immortalized Leydig cell lines (TM3, R2C, MA-10 and MLTC-1) derived from rat or mouse and the results of studies using these cells.
Additionally, the effects of the most commonly used environmental contaminants on Leydig cell function are discussed in the context of the impaired of steroidogenic pathway.
The results of several studies are presented which demonstrate that lycopene supplementation improves and maintaines the normal level of testosterone by improving the expression of StAR protein and steroidogenic enzymes in the Leydig cells of polychlorinated biphenyl exposed rats.
(Imprint: Nova)

Preface

Chapter 1. Immunological Function of Leydig Cells
(Ran Chen, Fei Wang and Daishu Han, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China)

Chapter 2. Leydig Cell Lines: In Vitro Models for Testosterone Biosynthesis
(Nebahat Yildizbayrak and Melike Erkan, Department of Biology, Istanbul University, Istanbul, Turkey)

Chapter 3. The Role of Environmental Contaminants in Leydig Cell Steroidogenesis
(Banu Orta Yilmaz and Melike Erkan, Department of Biology, Faculty of Science, Istanbul University, Istanbul, Turkey)

Chapter 4. Effect of Endocrine Disruptors (PCBs/DEHP) on Testicular Leydig Cells in Adult and f1 Male Offspring Rats
(J. Arunakaran, Former Professor and Head, Department of Endocrinology, Dr. ALM PG Institute of Basic Medical Science, University of Madras, Taramani, Chennai, India)

Chapter 5. Bibliography

Index

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