Leucocytes: The Great Guards of the Heart

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Authors: Ram B Singh, Jan Fedacko, Dominik Pella, and Petra Fedackova
Published in: World Heart Journal, Volume 9 Issue 4 (2017)
Page Range: 273-277
ISSN: 1556-4002

ISBN: N/A Categories: ,

Table of Contents

ABSTRACT

The year 2016-17 brought us several studies on the pathophysiology of acute coronary syndrome (ACS) and heart failure in particular, on the role of basophils, eosinophils, neutrophils and macrophages in the mechanism of diseases [1-8]. It is surprising to know the pathobiology of very late stent thrombosis and the role of neutrophils in ventricular remodeling [2]. Recent studies have also been published on the early diagnosis of ACS by high-sensitivity troponin (hsTn) and the role of new exciting biomarkers and clinical scores on risk stratification [9].
The heart never stops working despite deep sleep. The developing heart, while forming cardiomyocytes and fibroblasts, is the earliest organ to function in the embryo, generating rhythmic contractions before there is blood to pump [4]. The human heart rarely misses a beat, contracting and relaxing some 3 billion times during a normal life span [4]. This review aims to highlight the role of various cells in cardiovascular function during ACS and heart failure.