Leptin: Biosynthesis, Functions and Clinical Significance


Edward L. Blum (Editor)

Series: Endocrinology Research and Clinical Developments
BISAC: MED027000

Leptin was originally described for its role in obesity and energy homeostasis. This book focuses on the biosynthesis, functions and overall clinical significance of leptin. Leptin’s association to Alzheimer’s diseases and other cognitive disorders is discussed along with the leptin-renal axis; the relationship of leptin and melanoma; the inhibition of oncogenic effects of leptin by cAMP elevation in triple negative breast cancer cells; the leptin regulation of intestinal nutrients absorption; the implications of leptin in male reproductive function; the role of leptin in early life metabolism and its physiological, pathological, and potential therapeutic implications; the skeletal effects of leptin; the physiological roles of leptin in oral and maxillofacial region; the respiratory responses to microinjectons of leptin; and leptin as a reproductive modulator. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Leptin in Alzheimer’s Disease and other Cognitive Disorders and its Association with Underlying Lipid Abnormalities
(Jane M. Johnston, George Perry, J. Wesson Ashford, Nikolaos Tezapsidis, Neurotez Inc., Bridgewater, NJ, USA, and others)

Fat, Salt and Blood Pressure: The Leptin-Renal Axis
(Cristian Del Carpio Tenorio, Pramesh Dhakal, Garry P. Reams, Ronald H. Freeman, Robert Spear, Kan Liu, Daniel Villarreal, Department of Internal Medicine, SUNY- Upstate Medical University, NY, USA, and others)

Melanoma and Leptin
(Arash Sabetisoofyani, University of Arizona, Arizona, USA)

Inhibition of Oncogenic Effects of Leptin by cAMP Elevation in Triple Negative Breast Cancer Cells
(Annamaria Spina, Francesca Di Maiolo, Luigi Sapio, Luca Sorvillo, Silvio Naviglio, Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Medical School, Naples, Italy)

Leptin: From Energy Balance to Inflammatory Process in Obesity
(Flávia Campos Corgosinho, Andrea Frontini, Antonio Giordano, Saverio Cinti, Ana Raimunda Dâmaso, Departamento de Pós-Graduação em Nutrição, Universidade Federal de São Paulo, Brazil, and others)

Leptin Regulation of Intestinal Nutrients Absorption
(Jaione Barrenetxe, Carmen Fanjul, María Pilar Lostao, Department of Nutrition, Food Science and Physiology, University of Navarra, Pamplona, Spain)

Implications of Leptin in Male Reproductive Function
(Luc J. Martin, Biology Department, Université de Moncton, Moncton, New-Brunswick, Canada)

Role of Leptin in Early Life Increases the Metabolic Vulnerability in Adults: Physiological, Pathological and Potential Therapeutic Implications
(L. Manuel Apolinar, E. de la Chesnaye Caraveo, Endocrine Research Unit, Centro Médico Nacional, Instituto Mexicano del Seguro Social (IMSS), Mexico City, Mexico, and others)

The Skeletal Effects of Leptin
(Natalie K. Y. Wee, Paul A. Baldock, Osteoporosis and Bone Biology Division, Garvan Institute for Medical Research, Australia, and others)

The Physiological Roles of Leptin in the Oral and Maxillofacial Region: Promotive Effects on Mucosal Wound Healing and Tooth Development
(Reiko Tokuyama, Kazuhito Satomura, Department of Oral Medicine and Stomatology, Second Department of Oral and Maxillofacial Surgery, School of Dental Medicine, Tsurumi University, Japan)

Respiratory Responses to Microinjections of Leptin into the Pre-Bötzinger Complex of the Rat
(Alexey N. Inyushkin, Elena M. Inyushkina, Department of Human and Animal Physiology, Samara State University, Russian Federation)

Leptin as a Reproductive Modulator: An Eco-Physiological Approach
(Elena Bukovetzky, Abraham Haim, Haifa University, Environmental Biology and Endocrinology, Israel)


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