Leiomyosarcoma: Risk Factors, Diagnosis and Treatment Options


Rosemary H. Leach (Editor)

Series: Cancer Etiology, Diagnosis and Treatments
BISAC: MED062000

Leiomyosarcomas (LMS) are soft tissue tumors derived from smooth muscles cells, often in the uterus, retroperitoneum, skin, vessels, and bone. They are one of the most common types of sarcoma. Most leiomyosarcomas are sporadic, but may develop in the setting of genetic syndromes such as hereditary retinoblastoma and L-Fraumeni syndrome. Leiomyosarcomas may also be a result of radiation exposure; however, radiation-induced sarcomas are typically undifferentiated, fibrosarcomas or malignant peripheral nerve sheath tumors.

Like other sarcomas, prognosis is worse with higher grade tumors. Although chemotherapy and radiation are sometimes used as adjuvant therapy, the mainstay of therapy, and the only chance for cure, is surgery. The management of LMS is especially complex when the tumor involves major blood vessels. This book discusses the diagnosis and treatments most effectively used for Leiomyosarcomas. It also provides insight on the specific areas that LMS is found and how it affects that area. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Chapter 1 – Surgical Management of Leiomyosarcoma Involving the Major Abdominal Vessels (pp. 1-74)
Joshua Weiner, Adam Griesemer and Tomoaki Kato (Columbia University College of Physicians and Surgeons, Center for Liver Disease and Transplantation, New York, NY, USA)

Chapter 2 – Leimyosarcomas of the Genitourinary Tract (pp. 75-90)
Eun-mi Yu, Adam Kittai and Jeanny B. Aragon-Ching (Department of Medicine, Division of Hematology/Oncology, George Washington University Medical Center, Washington, DC, USA, and others)

Chapter 3 – Reconstructive Challenges in Leiomyosarcoma (pp. 91-110)
John A. M. Paro, M.D., Eric J. Wright, M.D., Tiffany Chen, B.S. and Gordon K. Lee, M.D., FACS (Stanford University Hospital and Clinics, Palo Alto CA, USA)

Chapter 4 – Diagnosis and Treatment of Leiomyosarcomas (pp. 111- 128)
Meena Bedi, M.D., David M. King, M.D. and Eduardo Zambrano, M.D. (Departments of Radiation Oncology, Orthopaedic Surgery and Pathology, Medical College of Wisconsin, WI, USA)

Chapter 5 – Primary Intracranial Leiomyosarcoma (pp. 129-134)
Zhenggang Xiong, M.D. (Department of Pathology, Tulane University School of Medicine, New Orleans, LA, USA)

Chapter 6 – Adult Urologic Leiomyosarcomas (pp. 135-152)
Manuel Soto-Delgado, M.D., Pastora Beardo-Villar, M.D., David Corrales-Mateo, M.D. and Álvaro Juárez-Soto, M.D. (Department of Urology of the Jerez Hospital, Spain, and others)

Chapter 7 – Cardiac Leiomyosarcoma (pp. 153-170)
Nedal Omran, M.D., Jan Laco, M.D., Ph.D., Petr Habal, M.D., Ph.D. and Jan Harrer, M.D., Ph.D. (Department of Cardiac Surgery, Faculty of Medicine and Faculty Hospital, Hradec Kralove, Czech Republic, and others)

Chapter 8 – Cutaneous Leiomyosarcoma (pp. 171-180)
Sara Alcántara Luna, Ana Delina Lozano Salazar, Lara Ferrándiz Pulido and Juan José Ríos-Martín (Unidad de Gestión Clínica de Dermatología del Hospital Universitario Virgen Macarena, Sevilla, Spain, and others)

Chapter 9 – Diagnosis and Pitfalls of Uterine Leiomyosarcoma (pp. 181-196)
Rani Kanthan and Jenna-Lynn Senger (Department of Pathology & Laboratory Medicine, University of Saskatchewan, Saskatoon, SK, Canada)

Chapter 10 – Clinical Manifestation and Imaging Diagnosis of Leiomyosarcoma (pp. 197-212)
Ying Wang and Ri-sheng Yu (Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine)

Chapter 11 – Gastrointestinal Leiomyosarcoma (GI-LMS) and GI Stromal Tumor (GIST) (pp. 213-226)
Kensuke Adachi, M.D., Ph.D. and Kazuaki Enatsu, M.D., Ph.D. (Department of Surgery, Tokyo Metropolitan Tama Medical Center, Tokyo, Japan)

Chapter 12 – Primary Ovarian Leiomyosarcoma: A Very Rare Entity (pp. 227-232)
Georgios Androutsopoulos, Emmanouil Terzakis and Georgios Decavalas (Department of Obstetrics and Gynecology, University of Patras, Medical School, Rion, Greece, and others)

Chapter 13 – Leiomyosarcoma in the Female Genital Tract: Risk Factors, Diagnosis and Treatment Options (pp. 233-244)
Joo-Hyun Nam, M.D., Ph.D. and Jeong-Yeol Park, M.D., Ph.D. (Department of Obstetrics and Gynecology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea)


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