Laminins: Structure, Biological Activity and Role in Disease


Demetrius C. Adams (Editor)
Emil O. Garcia (Editor)

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

Laminins are major proteins in the basal lamina (one of the layers of the basement membrane), a protein network foundation for most cells and organs. Laminins are an important and biologically active part of the basal lamina, influencing cell differentiation, migration, and adhesion, as well as phenotype and survival. In this book, the authors present current research in the study of the structure, biological activity and role in disease of laminins.

Topics include the key roles of laminins from embryos to adult skeletal muscle; Laminin-332 and integrins; anosmin-1 and galectin-1 as laminin interactors in nervous system development and pathology; loss of laminin alpha two; role of laminin in epithelial morphogenesis in the liver; laminins in uterine remodeling and embryo development during pregnancy; human gingival laminin-332 degradation by oral bacteria; and laminins as a modulator of the axonal response to guidance cues. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents


Laminins: Key Roles from Embryos to Adult Skeletal Muscles
(Michèle Beaudry, Valérie Bello, Thierry Darribère, Université Paris 13 Sorbonne Paris Cité, UFR-SMBH, Laboratoire Réponses Cellulaires et Fonctionnelles à l’Hypoxie, Bobigny, France, and others)

Laminin-332 and Integrins: Signaling Platform for Cell Adhesion and Migration and its Regulation by <i>N</i>-Glycosylation
(Yoshinobu Kariya, Yukiko Kariya, Jianguo Gu, Departments of Biochemistry and Diagnostic Pathology, Fukushima Medical University School of Medicine, Hikarigaoka, Fukushima, Japan, and others)

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Anosmin-1 and Galectin-1 as Laminin Interactors in Nervous System Development and Pathology
(Silvia Velasco, Fernando de Castro, Grupo de Biología de Membrana y Reparación Axonal, Hospital Nacional de Parapléjicos-SESCAM, Toledo, Spain, and others)

A Potential Role of Laminins and 37 kDa Laminin Receptor Precursor (LRP)/67 kDa Laminin Receptor (LR) in Disease
(Jisuk Yun, Department of Food Safety Evaluation, Korea Food and Drug Administration, Cheongwon-gun, Republic of Korea)

Loss of Laminin Alpha Two
(Mahasweta Girgenrath, Tanya Girgenrath, Department of Health Sciences, Boston University, Boston, MA, USA, and others)

Roles of Laminins in Epithelial Morphogenesis in the Liver
(Naoki Tanimizu, Yamato Kikkawa, Toshihiro Mitaka, Department of Tissue Development and Regeneration, Research Institute for Frontier Medicine, Sapporo Medical University School of Medicine, Japan, and others)

Role of Laminin on Uterine Remodeling and Embryo Development during Pregnancy
(Bruno Zavan, Andréa Mollica do Amarante-Paffaro, Valdemar Antonio Paffaro Junior, Integrative Animal Biology Laboratory – LABAInt, Biomedical Science Institute, UNIFAL-MG, Alfenas, MG, Brazil)

Human Gingival Laminin-332 Degradation by Oral Bacteria
(Pirjo Pärnänen, Timo Sorsa, Institute of Dentistry, University of Helsinki and Department of Oral and Maxillofacial Diseases, Helsinki University Central Hospital, Finland)

Commentary: Laminins as a Modulator of the Axonal Response to Guidance Cues
(Tomoyuki Masuda, Takashi Shiga, Hiroyuki Yaginuma, Shuichi Ueda, Department of Histology and Neurobiology, Dokkyo Medical University School of Medicine, Tochigi, Japan, and others)


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