Lactoferrin: Structure, Biological Functions, Health Benefits and Clinical Applications

Tzi Bun Ng (Editor)
Prof. of Biochemistry, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, China

Jack Wong (Editor)
The Chinese University of Hong Kong, China

Ryan Tse (Editor)
Vita Green Pharmaceutical (Hong Kong) Ltd., Hong Kong

Tak Fu Tse (Editor)
The University of Hong Kong, Hong Kong

Helen Chan (Editor)
Vita Green Pharmaceutical (Hong Kong) Ltd., Hong Kong
School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, China

Series: Biochemistry Research Trends
BISAC: MED008000

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Lactoferrin is a multifunctional whey glycoprotein with a molecular mass of about 80 kDa. It is produced by various mammals and is found in milk, nasal secretions, saliva and tears, and it is in great abundance in human colostrum. It has intrigued scientists for decades. Lactoferricin and lactoferrampin are bioactive peptides derived from lactoferrin. Topics discussed in this book encompass: the primary structure and glycosylation pattern of milk lactoferrin, the inhibitory effect of lactoferrin on the hepatitis C virus, the anti-candidal activities of lactoferrin in systemic candidiasis, antimicrobial (antibacterial, antifungal and antiviral) and anticancer activities of lactoferricin, activities of lactoferrampin and the mechanisms involved, the properties and activities of lactoferrampin and lactoferricin-lactoferrampin chimera, dependence of the multiple effects of lactoferrinon receptors in different cell types, and clinical applications of lactoferrin. (Imprint: Nova)

Preface

Chapter 1. Lactoferrin: A Ubiquitous and Multifunctional Protein, Intriguing Scientists for over Seventy Five Years (pp. 1-30)
Ewa Skar¿yñska, Tzi Bun Ng and Barbara Lisowska-Myjak

Chapter 2. The Primary Structure and Glycosylation Pattern of Milk Lactoferrins (pp. 31-48)
Serafina Gallina, Rosaria Saletti, Vincenzo Cunsolo, Vera Muccilli and Salvatore Foti

Chapter 3. Lactoferrin and Hepatitis C Virus: Flexible Fitting and Invasive Mechanism (pp. 49-72)
Nawal Abd El-Baky, Esmail M. El-Fakharany and Elrashdy M. Redwana

Chapter 4. Anti-Candidal Activities of Lactoferrin in Systemic Candidiasis (pp. 73-98)
Kabilan Velliyagounder and Mariam Aldajani

Chapter 5. Antimicrobial Activities of the Lactoferrin-Derived Peptide Lactoferricin (pp. 99-112)
Jack Ho Wong, Tzi Bun Ng, Chit Tam, Charlene Cheuk Wing Ng, Ryan Tse, Tak Fu Tse, Helen Chan, Ewa Skar¿yñska and Barbara Lisowska-Myjak

Chapter 6. Properties and Activities of Lactoferrampin (A Lactoferrin-Derived Peptide) and Its Chimera with Lactoferricin (pp. 113-130)
Jack Ho Wong, Tzi Bun Ng, Chit Tam, Charlene Cheuk Wing Ng, Ryan Tse, Tak Fu Tse and Helen Chan

Chapter 7. Anticancer Activities of Lactoferricin Derived from Lactoferrin (pp. 131-146)
Jack Ho Wong, Tzi Bun Ng, Chit Tam, Charlene Cheuk Wing Ng, Ryan Tse, Tak Fu Tse and Helen Chan

Chapter 8. Multiple Effects of Lactoferrin Depend on Diverse Receptors for the Protein in Different Cell Types (pp. 147-184)
Sergio Ghersevich, Luciana Filocco, Carlos Zumoffen, and Estefanía Massa

Chapter 9. Clinical Applications of Lactoferrin (pp. 185-220)
Kallirroi S. Kyriakidi and Dimitrios K. Christodoulou

About the Editor (pp. 221-224)

Index (pp. 225)

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