Lactate Dehydrogenase (LDH): Biochemistry, Function and Clinical Significance

Reshma Rani
Amity Institute of Biotechnology, Amity University Noida, Noida, Uttar Pradesh, India

Vinit Kumar
Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Noida, Uttar Pradesh, India

Series: New Developments in Medical Research
BISAC: SCI017000

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The book entitled “Lactate Dehydrogenase (LDH): Biochemistry, Functions and Clinical Significance” provides a broad and authoritative review of the lactate dehydrogenase enzyme, including its isoforms, catalytic functions, distribution in various tissues, involvement in cancer cell metabolism and tumorigenesis, involvement in the plasmodium enzyme, various small molecule inhibitors of hLDHA and pfLDH, and clinical significance. Recent research and review articles are included to improve the book’s significance in the area of research, particularly in cancer treatment, diagnosis, and drug discovery.

Although the chapters can be read independently from one another, the whole book is arranged in seven chapters for the convenience of the reader. The first chapter covers the importance of the hot topic, LDH targets, and the second chapter provides an overview of LDH and its involvement in cancer cell metabolism. The third chapter provides the various isoforms of LDH and the basics of catalytic functions of LDHA. All three chapters can serve as an introduction for those who are new to the research area of LDH. Chapters four and five deliver an overview of various small molecules as inhibitors of hLDHA and pfLDHA, respectively. These two chapters are useful to the researcher working in the fields of drug design and drug discovery in the areas of cancer and malaria research. The last two chapters focus on the importance of LDH as a biomarker, and its importance in disease diagnosis and prognosis in clinical settings.

All of the chapters discuss the latest research findings that have occurred over the last few years. Bringing all the information together in one major reference, the authors systematically reviewed and summarized these recent research findings, providing an in depth understanding of the role of LDH and its applications in research and clinical practice.

Readership: Overall, this book is a complete package for graduates, students, and researchers providing basic information about LDH, and its importance in research and clinical settings. This book is helpful to the researcher engaged in the fields of LDH, drug design and drug discovery, the development of biomarkers, disease diagnosis, and prognosis, etc.
(Imprint: Nova)

Preface

Chapter 1. Lactate Dehydrogenase Enzyme: An Old Enzyme but New Viable Target Offers New Hope in Cancer Therapeutics
(Vinit Kumar, PhD, Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Noida, Uttar Pradesh, India and Reshma Rani, PhD, Amity Institute of Biotechnology, Amity University Noida, Uttar Pradesh, India)

Chapter 2. Lactate Dehydrogenase: The Role in the Warburg Effect and Cancer
(Nazia Nazam, Ravi Teja Chavata and Pallavi Agarwal, Amity Institute of Molecular Medicine and Stem Cell Research, Amity University, Noida, U.P., India)

Chapter 3. Lactate Dehydrogenase, Its Isoforms, and Its Catalytic Functions
(Aditi Dhawan and Kajal Kanchan, School of Biotechnology, Jawaharlal Nehru University, New Delhi, and others)

Chapter 4. Small Molecules: Potential Inhibitors of the Human Lactate Dehydrogenase A Enzyme
(Vinit Kumar, Amity Institute of Molecular Medicine and Stem Cell Research, Amity University Noida, Uttar Pradesh, India)

Chapter 5. Small Molecules Inhibitors of the Plasmodium falciparum LDH Enzyme and Their Therapeutic Applications
(Reshma Rani, Amity Institute of Biotechnology, Amity University Noida, Uttar Pradesh, India)

Chapter 6. Lactate Dehydrogenase: A Biomarker for Disease Diagnosis and Prognosis
(Reshma Rani, Amity Institute of Biotechnology, Amity University Noida, Uttar Pradesh, India, and others)

Chapter 7. LDH and Its Clinical Significance
(Awanish Kumar and Ashwini Kumar, Department of Biotechnology, National Institute of Technology Raipur, Raipur, Chhattisgarh, India)

About the Editors

Index

Keywords: Importance of Warburg Effect, Lactate Dehydrogenase enzyme, Clinical significance of LDH enzyme, LDHA: Viable target of cancer, Drug Discovery

This book is a complete package for graduates, students, and researchers providing basic information about LDH, and its importance in research and clinical settings. This book is helpful to the researcher engaged in the fields of LDH, drug design and drug discovery, the development of biomarkers, disease diagnosis, and prognosis, etc.

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