Keratinocytes: Structure, Molecular Mechanisms and Role in Immunity


Elia Ranzato (Editor)
University of Piemonte Orientale, DiSIT- Dipartimento di Scienze e Innovazione Tecnologica, Alessandria, Italy

Series: Cell Biology Research Progress
BISAC: SCI017000

The human skin is constantly exposed to a large number of external pathogens, due to daily contact with the environment. The observation that extensive skin infections are relatively rare suggests the presence of an efficient host defense system at the skin surface.

Recent findings indicate the importance of keratinocytes as effectors of innate immunity, but also as regulators of acquired immune responses, inflammation and wound repair. This book considers the current findings regarding the role of keratinocytes in the epidermis with special interest to mechanisms involved in host defense. Finally, the clinical relevance of the functions of keratinocytes in the innate immunity is also discussed. (Imprint: Nova Biomedical )

Table of Contents

Table of Contents

Preface pp. i-viii

Chapter 1. Dynamic Interplay between Cell Types during Wound Healing
(Simona Martinotti and Elia Ranzato, DiSIT – Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale “Amedeo Avogadro”, Italy)pp. 1-12

Chapter 2. Regulation of the Proliferation and Differentiation of Keratinocytes and Cellular Interaction between Keratinocytes and the Tissue Environment
(Tomohisa Hirobe, Fukushima Restoration Support Headquarters, National Institute of Radiological Sciences, Anagawa, Inage-ku, Chiba, Japan)pp. 13-38

Chapter 3. Keratinocyte Differentiation: Focus on MAPK Signal Transduction
(Tanja Popp and Christian Ries, Institute for Cardiovascular Prevention, Ludwig-Maximilians-University of Munich (LMU), Germany)pp. 39-68

Chapter 4. Epithelial-to-Mesenchymal Transition in Epidermal Keratinocytes
(Ekaterina A. Vorotelyak, Vasily V. Terskikh and Andrey V. Vasiliev, N.K. Koltsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia)pp. 69-108

Chapter 5. Keratinocytes: Gatekeeper in Innate Defense
(Yuping Lai, Shanghai Key Laboratory of Regulatory Biology, School of Life Sciences, East China Normal University, Shanghai, P.R. China)pp. 109-116
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Chapter 6. Mechanisms for Keratinocyte Immune Defense: Implications for Cutaneous Wound Healing
(Juan L. Rendon and Katherine A. Radek, Loyola University Chicago, Health Sciences Campus, Department of Surgery, Maywood, IL, USA)pp. 117-134

Chapter 7. Keratinocytes and Anti Microbial Peptides: Influence of Extremely Low Frequency Electromagnetic Field (ELF-EMF)
(Giovina Vianale, Matteo Auriemma, Paolo Amerio and Marcella Reale, University “G. d’Annunzio”, Chieti-Pescara, Chieti, Italy)pp. 135-152

Index pp. 153-164

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