Isoprenoids: Polyprenols and Polyprenyl Phosphates as Physiologically Important Metabolic Regulators

Alexander N. Narovlyansky
N.F. Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Alexander V. Pronin
N.F. Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Alexander V. Sanin
N.F. Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Vladimir V. Veselovsky
N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation
Leonid L. Danilov
N.D. Zelinsky Institute of Organic Chemistry of the Russian Academy of Sciences, Moscow, Russian Federation
Alexander M. Sedov
N.F. Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation
Felix I. Ershov
N.F. Gamaleya National Research Center of Epidemiology and Microbiology of the Ministry of Health of the Russian Federation, Moscow, Russian Federation

Series: Chemistry Research and Applications
BISAC: SCI013040

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$95.00

Volume 10

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Special issue: Resilience in breaking the cycle of children’s environmental health disparities
Edited by I Leslie Rubin, Robert J Geller, Abby Mutic, Benjamin A Gitterman, Nathan Mutic, Wayne Garfinkel, Claire D Coles, Kurt Martinuzzi, and Joav Merrick

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This book defines and classifies polyisoprenoids, describes the characteristics of polyprenols, dolichols and their phosphates, and the metabolism of polyprenols and their derivatives, discusses the biological role of polyprenols, and analyzes the function of polyprenols in the regulation of cholesterol synthesis and the role of phytosterols in the suppression of cholesterol absorption in the gastrointestinal tract.

It also describes the hepatoprotective and anti-inflammatory effect of polyprenols and separately discusses the current understanding of the mechanisms of dyslipidemia and metabolic syndrome development. This review contains background information on the newly developed drugs based on polyprenols and polyprenyl phosphates, which are highly promising in veterinary and human medicine.

Introduction

Chapter 1. Polyisoprenoids and the Isoprenoid System: Definition and Classification

Chapter 2. Metabolism of Polyprenols and Their Derivatives

Chapter 3. Biological Role of Polyprenols and Dolichol

Chapter 4. General Principles of Preparation of Phosphopolyprenols and Their Glycosyl Esters

Chapter 5. Approaches to the Search for Antibacterial Drugs Based on Polyprenols

Chapter 6. Polyprenols and Their Derivatives as Potential Objects for Molecular Medicine

Chapter 7. Approaches to the Prevention and Treatment of Atherosclerosis with Polyprenols

Chapter 8. Metabolic Syndrome and Polyprenyl Phosphates

Chapter 9. Experimental Investigation of Specific and General Pharmacological Activity of Sodium Polyprenyl Phosphate (PPPhNa)

Chapter 10. Experience in the Use of Polyprenyl Phosphates in Veterinary Medicine

Chapter 11. Polyisoprenoid-Based Drugs

Conclusion

References

Keywords: polyisoprenoids, polyprenols, dolichols and their phosphates, metabolism of polyprenols and their derivatives, antiviral, hepatoprotective and anti-inflammatory effect of polyprenols, dyslipidemia, and metabolic syndrome

It is of great interest to a wide range of readers, including chemists, biologists, pharmacologists and physicians.

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