Introduction to Drug Designing and Development

Rajnish Kumar, Anju Sharma and Rajesh Kumar Tiwari (Editors)
Amity Institute of Biotechnology, AMITY University, Lucknow Campus, Uttar Pradesh, India

Series: Pharmacology – Research, Safety Testing and Regulation
BISAC: MED058170

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This book is useful to readers who are just beginning in the field of drug design and development. It starts with an introduction and some basic information about drugs. Pharmacokinetic and pharmacodynamic aspects are covered in the initial chapters. Systemic descriptions of pharmacokinetic parameters such as absorption, distribution, metabolism, and excretion are explained in simple and easy language. This book demonstrates detailed concepts of lead molecules and their sources.

In addition, drug target classification, identification and validation strategies, as well as the design and development of combinatorial libraries for new lead generation are also covered. This book contains various methodologies, such as structure-based drug designing, quantitative structure activity relationship, pharmacophore modeling, and docking studies for screening and designing the drug candidates. This book will help in the identification and design of drugs that could be potentially useful in deriving the candidate drugs, which may have efficacy in animal models or cell cultures.

Thus, the most effective compounds could be employed based on the above results, and will then be moved from preclinical studies to clinical trials. The last couple of chapters describe dosage drug regulatory affairs and recent advancements in healthcare. The aim of this book is to provide comprehensive ideas about overall drug design and development. (Imprint: Nova Biomedical )

Preface pp,vii-viii

Chapter 1. Drugs: Introduction and Definition
(Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,1-14

Chapter 2. Pharmacokinetics
(Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,15-38

Chapter 3. Pharmacodynamics
(Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,39-48

Chapter 4. Plants as a Source of Lead Molecules
(Mala Trivedi, Anju Sharma and Suresh Kumar Yadav, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,49-80

Chapter 5. Animals as a Source of Lead Molecules
(Gunjan Pandey and J.K. Srivastava, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India and others)pp,81-98

Chapter 6. Drug Targets and Validation Techniques
(Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,99-110

Chapter 7. Screening of Drugs
(Swati Srivastava, Lovely Professional University, Phagwara, Punjab, India)pp,111-122

Chapter 8. Structure-Based Drug Designing
(Anju Sharma and Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,123-140

Chapter 9. Concepts of Combinatorial Library
(Anju Sharma, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,141-160

Chapter 10. Quantitative Structure Activity Relationship
(Anju Sharma, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,161-214

Chapter 11. Pharmacophore Modeling
(Rajnish Kumar, Amity Institute of Biotechnology, AMITY University-Uttar Pradesh, Lucknow, Uttar Pradesh, India)pp,215-224

Chapter 12. Drug Formulation and Dosage Forms
(Prakash Deep and Amrit Kumar Singh, Amity Institute of Pharmacy, Amity University Uttar Pradesh, Lucknow Campus, India)pp,225-234

Chapter 13. Drug Regulatory Affairs
(Abhishek Kumar, Amity Institute of Biotechnology, AMITY University Uttar Pradesh, Lucknow Campus, Uttar Pradesh, India)pp,235-244

Chapter 14. Recent Advances in Healthcare and Development of Biomedical Sensors
(Ashok Kumar Mishra, Department of Physics, Amity University Uttar Pradesh, Lucknow Campus, India)pp,245-258

Index p,259-278

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