Intrinsically Disordered Proteins (IDPs): Structural Characterization, Therapeutic Applications and Future Directions

Violet Weber

Series: Protein Biochemistry, Synthesis, Structure and Cellular Functions
BISAC: SCI007000

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Intrinsically disordered proteins (IDPs) are biomolecules that do not have a definite 3D structure; their role in the biochemical network of a cell relates to their ability to switch rapidly among different secondary and tertiary structures. The emergence of IDPs has challenged the classical protein structure-function paradigm. IDPs play an important role in cellular regulation, signaling and control in health and disease. However, the unusual biophysics of these proteins makes structural characterization of IDPs and their complexes not only challenging but often resulting in opposite conclusions.

This book studies the structural characterization and future directions of IDPs. Chapter One focuses on the DNA-binding IDPs and how intrinsic disorder affects their function. Chapter Two discusses the use of a computer atomistic simulation for the structural analysis of IDPs. The final chapter, Chapter Three, examines two long-standing contradictions concerning dimerization and membrane-binding activities of IDPs; provides an explanation of these discrepancies; and demonstrates how the resolution of these critical issues in the field results in the expanded understanding of cell function with multiple applications in biology and medicine.
(Imprint: Nova)

Preface

Chapter 1
Intrinsic Disorder in DNA-Binding Proteins
(Alicia Roque, Inma Ponte1 and Pedro Suau, Departamento de Bioquímica y Biología Molecular, Facultad de Biociencias, Universidad Autónoma de Barcelona, Spain)

Chapter 2
Structural Analysis of Intrinsically Disordered Proteins: Computer Atomistic Simulation
(Anna Battisti, Gabriele Ciasca and Alexander Tenenbaum, International School for Advanced Studies (SISSA), Trieste, Italy, and others)

Chapter 3
Biophysical Characterization of Intrinsically Disordered Proteins and Their Complexes: Challenges and Contradictions
(Alexander B. Sigalov, SignaBlok, Inc., Shrewsbury, MA, USA)

Index

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