Intracytoplasmic Sperm Injection (ICSI): Clinical Considerations, Outcomes and Potential Health Effects


Murid Javed (Editor) – Laboratory Director at OriginElle Fertility Clinic and Women’s Health Centre, Ottawa and Montreal, Canada

Series: Human Reproductive System – Anatomy, Roles and Disorders

BISAC: MED082000

Target Audience: This book is very useful for medical students, andrologists, embryologists, nurses or anyone else interested in learning basic or advanced knowledge of assisted reproductive technology, especially ICSI.

This book provides comprehensive information on Intracytoplasmic Sperm Injection (ICSI), its clinical considerations, outcomes and potential health effects. Male and female infertility is increasing all over the world. The basic techniques of assisted reproduction like ovulation control and intrauterine insemination are ineffective if the sperm quality or number is inadequate. The advanced fertilization techniques are in-vitro fertilization (IVF) and ICSI. In 15% cases of infertility, IVF results in total failed fertilization; therefore, ICSI must be used. Some clinics exclusively use ICSI for all infertility patients due to its reliability of fertilization outcome or to avoid total fertilization failure.

ICSI was first used in humans in 1992. Since then, tremendous advances have been made in assisted reproductive technology. ICSI has enabled even those men who have rare sperm in their testes to father a biological child. If no sperm are observed in the ejaculate, in almost all cases, they can be recovered from the testicles. Such retrieved sperm can only be used by ICSI. Therefore, its understanding is essential not only for medical staff but also for patients suffering from infertility.

This book is highly recommended for patients suffering from infertility or currently undergoing infertility treatment. It explains the factors affecting ICSI success rate. In ICSI, the embryologist picks a sperm for injection to fertilize oocytes whereas in intrauterine insemination and IVF, one sperm penetrates naturally. This manual selection of sperm has raised concerns especially in those patients suffering from severe male factor infertility. The nature of sperm defects varies and could be congenital, acquired or genetic. Children born through ICSI are, therefore, considered at higher risk of carrying the defect. Many investigations have been carried out to compare incidence of the defects between children conceived naturally and conceived through ICSI. Additional technologies have been developed to ensure the birth of a normal child. These include pre-implantation genetic testing and non-invasive prenatal testing. This book addresses these concerns and explains the health effects on children born through ICSI.

The authors of the chapters of this book are highly experienced and from different parts of the world. Many of them are directing very busy ART laboratories at leading infertility clinics in the United States of America, Canada and the Middle East.

Table of Contents

(Murid Javed, PhD, EMB – Originelle Fertility Clinic and Women’s Health Centre, Ottawa, Canada)

Chapter 1. Factors Affecting Intracytoplasmic Sperm Injection Fertilization Rate
(Iman Halvaei, PhD; Navid Esfandiari, PhD, HCLD – Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran, et al.)

Chapter 2. The Effects of Sperm Quality on Embryo Development After Intracytoplasmic Sperm Injection. Part 1: Current Status and Future Areas of Investigation
(Salman Ali Aldakhilallah; Naif Hamdan Alharbi; Yousef Al Helou; Nafisa Ali; Jaffar Ali, PhD – Department of Reproductive Endocrine and Infertility Medicine, King Fahad
Medical City, Riyadh, Saudi Arabia, et al.)

Chapter 3. The Effects of Sperm Quality on Embryo Development After Intracytoplasmic Sperm Injection. Part 2: Impact of Sperm on Embryo Quality and Treatment Outcome
(Yousef Al Helou; Salman Ali Aldakhilallah; Naif Hamdan Alharbi; Nafisa Ali; Jaffar Ali, PhD – Fakih IVF Dubai, United Arab Emirates, et al.)

Chapter 4. Increasing Links Between Male Fertility and Defective Oocyte Activation: An Emerging Role for Phospholipase C Zeta
(Junaid Kashir, PhD; Serdar Coskun, PhD – Alfaisal University, College of Medicine, Riyadh, Saudi Arabia, et al.)

Chapter 5. Reconstruction of Zygote and Embryonic Development Following Microsurgical Restoration of the Diploid Constitution in the Human Tripronuclear Zygote.
(Abdul Munaf Sultan Ahamed, PhD – Anova Fertility & Reproductive Health, Toronto, Canada)

Chapter 6. Assisted Reproductive Technology Outcome Before and After ‎Varicocele Repair
(Hamed AlAli, MD; Naif AlHathal, MD – Department of Urology, King Fahad Specialist Hospital, Dammam, Saudi Arabia, et al.)

Chapter 7. Potential Health Effects of Intracytoplasmic Sperm Injection (ICSI)
(Murid Javed, PhD, EMB – Originelle Fertility Clinic and Women’s Health Centre, Ottawa, Canada)

Chapter 8. Possibility of Transmission of Paternal Genetic Defects Through Intracytoplasmic Sperm Injection (ICSI)
(Basmah Fraij Alomrani – Genetics Department, King Abdulaziz University, Jeddah, Saudi Arabia)


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